The global market for RNAi for Therapeutic was estimated to be worth US$ 2278 million in 2024 and is forecast to a readjusted size of US$ 13125 million by 2031 with a CAGR of 27.5% during the forecast period 2025-2031.
RNA interference (RNAi) therapeutics is an advanced molecular medicine technology that utilizes double-stranded RNA molecules (such as siRNA or shRNA) to selectively silence target gene expression, thereby blocking pathogenic gene transcription or translation to achieve precise treatment of various genetic disorders, rare diseases, cancers, and viral infections. Without altering the DNA sequence, RNAi therapy offers reversible, highly specific, and low-toxicity interventions at the RNA level. Since the approval of the first RNAi drug, the field has rapidly transitioned from research to commercialization, showing immense potential in targeting the liver, nervous system, and oncology. With breakthroughs in delivery systems and expanding clinical pipelines, RNAi therapeutics is emerging as a strategic pillar in precision medicine and gene therapy industries.
The global deployment of RNAi therapeutics is accelerating, driven by multiple dimensions: breakthroughs in genomics and RNA biology have enabled higher-precision drug design; advancements in novel delivery technologies such as lipid nanoparticles (LNP) and GalNAc conjugates have significantly improved targeting efficiency to the liver and other tissues; and fast-track review policies by regulatory agencies in multiple countries have shortened the path from R&D to commercialization. Leading pharmaceutical and biotech companies are actively expanding the range of clinical indications through mergers, acquisitions, and collaborations, facilitating the market rollout of RNAi therapies in rare diseases, metabolic disorders, and cardiovascular diseases.Despite its disruptive potential, RNAi therapeutics faces technical, commercial, and regulatory hurdles. Delivery efficiency and tissue specificity remain key bottlenecks, especially in achieving effective delivery to the central nervous system and solid tumors. Additionally, RNAi molecules may trigger non-specific immune responses or off-target effects, affecting both safety and efficacy. From a business perspective, high production costs and stringent quality control standards constrain scalability and profit margins. Intellectual property barriers and the concentration of core patents among a few leading companies further raise the technical and legal thresholds for new entrants.Demand in downstream markets is becoming increasingly segmented and diversified. Rare disease treatment, lacking effective therapies, is highly reliant on RNAi solutions, making it an early commercialization breakthrough. Cardiovascular and metabolic diseases, with their vast patient populations, offer long-term growth potential. In oncology and immunotherapy, RNAi is forming novel combination approaches with checkpoint inhibitors, CAR-T, and other treatments. With the rise of personalized medicine and companion diagnostics, RNAi therapies will become more deeply integrated into precision stratification and targeted intervention clinical pathways, driving demand toward higher efficiency, safety, and controllability.
This report aims to provide a comprehensive presentation of the global market for RNAi for Therapeutic, focusing on the total sales revenue, key companies market share and ranking, together with an analysis of RNAi for Therapeutic by region & country, by Type, and by Application.
The RNAi for Therapeutic market size, estimations, and forecasts are provided in terms of sales revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. With both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding RNAi for Therapeutic.
Market Segmentation
By Company
- Alnylam Pharmaceuticals
- Arrowhead Pharmaceuticals
- Arrowhead
- Silence Therapeutics
- Benitec Biopharma
- Phio Pharmaceuticals
- RXi Pharmaceuticals
- Arrakis Therapeutics
- Benitec Biopharma
- miRagen Therapeutics
- Sylentis
- Gradalis
- Sirnaomics
- Silenseed
Segment by Type
Segment by Application
- Cancer
- Cardiovascular
- HBV
- Others
By Region
- North America
- Asia-Pacific
- China
- Japan
- South Korea
- Southeast Asia
- India
- Australia
- Rest of Asia-Pacific
- Europe
- Germany
- France
- U.K.
- Italy
- Netherlands
- Nordic Countries
- Rest of Europe
- Latin America
- Mexico
- Brazil
- Rest of Latin America
- Middle East & Africa
- Turkey
- Saudi Arabia
- UAE
- Rest of MEA
Chapter Outline
Chapter 1: Introduces the report scope of the report, global total market size. This chapter also provides the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 2: Detailed analysis of RNAi for Therapeutic company competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 3: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Revenue of RNAi for Therapeutic in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the market development, future development prospects, market space, and market size of each country in the world.
Chapter 6: Revenue of RNAi for Therapeutic in country level. It provides sigmate data by Type, and by Application for each country/region.
Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product revenue, gross margin, product introduction, recent development, etc.
Chapter 8: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 9: Conclusion.
Table of Contents
1 Market Overview
- 1.1 RNAi for Therapeutic Product Introduction
- 1.2 Global RNAi for Therapeutic Market Size Forecast (2020-2031)
- 1.3 RNAi for Therapeutic Market Trends & Drivers
- 1.3.1 RNAi for Therapeutic Industry Trends
- 1.3.2 RNAi for Therapeutic Market Drivers & Opportunity
- 1.3.3 RNAi for Therapeutic Market Challenges
- 1.3.4 RNAi for Therapeutic Market Restraints
- 1.4 Assumptions and Limitations
- 1.5 Study Objectives
- 1.6 Years Considered
2 Competitive Analysis by Company
- 2.1 Global RNAi for Therapeutic Players Revenue Ranking (2024)
- 2.2 Global RNAi for Therapeutic Revenue by Company (2020-2025)
- 2.3 Key Companies RNAi for Therapeutic Manufacturing Base Distribution and Headquarters
- 2.4 Key Companies RNAi for Therapeutic Product Offered
- 2.5 Key Companies Time to Begin Mass Production of RNAi for Therapeutic
- 2.6 RNAi for Therapeutic Market Competitive Analysis
- 2.6.1 RNAi for Therapeutic Market Concentration Rate (2020-2025)
- 2.6.2 Global 5 and 10 Largest Companies by RNAi for Therapeutic Revenue in 2024
- 2.6.3 Global Top Companies by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in RNAi for Therapeutic as of 2024)
- 2.7 Mergers & Acquisitions, Expansion
3 Segmentation by Type
- 3.1 Introduction by Type
- 3.1.1 siRNA
- 3.1.2 miRNA
- 3.1.3 shRNA
- 3.2 Global RNAi for Therapeutic Sales Value by Type
- 3.2.1 Global RNAi for Therapeutic Sales Value by Type (2020 VS 2024 VS 2031)
- 3.2.2 Global RNAi for Therapeutic Sales Value, by Type (2020-2031)
- 3.2.3 Global RNAi for Therapeutic Sales Value, by Type (%) (2020-2031)
4 Segmentation by Application
- 4.1 Introduction by Application
- 4.1.1 Cancer
- 4.1.2 Cardiovascular
- 4.1.3 HBV
- 4.1.4 Others
- 4.2 Global RNAi for Therapeutic Sales Value by Application
- 4.2.1 Global RNAi for Therapeutic Sales Value by Application (2020 VS 2024 VS 2031)
- 4.2.2 Global RNAi for Therapeutic Sales Value, by Application (2020-2031)
- 4.2.3 Global RNAi for Therapeutic Sales Value, by Application (%) (2020-2031)
5 Segmentation by Region
- 5.1 Global RNAi for Therapeutic Sales Value by Region
- 5.1.1 Global RNAi for Therapeutic Sales Value by Region: 2020 VS 2024 VS 2031
- 5.1.2 Global RNAi for Therapeutic Sales Value by Region (2020-2025)
- 5.1.3 Global RNAi for Therapeutic Sales Value by Region (2026-2031)
- 5.1.4 Global RNAi for Therapeutic Sales Value by Region (%), (2020-2031)
- 5.2 North America
- 5.2.1 North America RNAi for Therapeutic Sales Value, 2020-2031
- 5.2.2 North America RNAi for Therapeutic Sales Value by Country (%), 2024 VS 2031
- 5.3 Europe
- 5.3.1 Europe RNAi for Therapeutic Sales Value, 2020-2031
- 5.3.2 Europe RNAi for Therapeutic Sales Value by Country (%), 2024 VS 2031
- 5.4 Asia Pacific
- 5.4.1 Asia Pacific RNAi for Therapeutic Sales Value, 2020-2031
- 5.4.2 Asia Pacific RNAi for Therapeutic Sales Value by Region (%), 2024 VS 2031
- 5.5 South America
- 5.5.1 South America RNAi for Therapeutic Sales Value, 2020-2031
- 5.5.2 South America RNAi for Therapeutic Sales Value by Country (%), 2024 VS 2031
- 5.6 Middle East & Africa
- 5.6.1 Middle East & Africa RNAi for Therapeutic Sales Value, 2020-2031
- 5.6.2 Middle East & Africa RNAi for Therapeutic Sales Value by Country (%), 2024 VS 2031
6 Segmentation by Key Countries/Regions
- 6.1 Key Countries/Regions RNAi for Therapeutic Sales Value Growth Trends, 2020 VS 2024 VS 2031
- 6.2 Key Countries/Regions RNAi for Therapeutic Sales Value, 2020-2031
- 6.3 United States
- 6.3.1 United States RNAi for Therapeutic Sales Value, 2020-2031
- 6.3.2 United States RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.3.3 United States RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.4 Europe
- 6.4.1 Europe RNAi for Therapeutic Sales Value, 2020-2031
- 6.4.2 Europe RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.4.3 Europe RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.5 China
- 6.5.1 China RNAi for Therapeutic Sales Value, 2020-2031
- 6.5.2 China RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.5.3 China RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.6 Japan
- 6.6.1 Japan RNAi for Therapeutic Sales Value, 2020-2031
- 6.6.2 Japan RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.6.3 Japan RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.7 South Korea
- 6.7.1 South Korea RNAi for Therapeutic Sales Value, 2020-2031
- 6.7.2 South Korea RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.7.3 South Korea RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.8 Southeast Asia
- 6.8.1 Southeast Asia RNAi for Therapeutic Sales Value, 2020-2031
- 6.8.2 Southeast Asia RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.8.3 Southeast Asia RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
- 6.9 India
- 6.9.1 India RNAi for Therapeutic Sales Value, 2020-2031
- 6.9.2 India RNAi for Therapeutic Sales Value by Type (%), 2024 VS 2031
- 6.9.3 India RNAi for Therapeutic Sales Value by Application, 2024 VS 2031
7 Company Profiles
- 7.1 Alnylam Pharmaceuticals
- 7.1.1 Alnylam Pharmaceuticals Profile
- 7.1.2 Alnylam Pharmaceuticals Main Business
- 7.1.3 Alnylam Pharmaceuticals RNAi for Therapeutic Products, Services and Solutions
- 7.1.4 Alnylam Pharmaceuticals RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.1.5 Alnylam Pharmaceuticals Recent Developments
- 7.2 Arrowhead Pharmaceuticals
- 7.2.1 Arrowhead Pharmaceuticals Profile
- 7.2.2 Arrowhead Pharmaceuticals Main Business
- 7.2.3 Arrowhead Pharmaceuticals RNAi for Therapeutic Products, Services and Solutions
- 7.2.4 Arrowhead Pharmaceuticals RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.2.5 Arrowhead Pharmaceuticals Recent Developments
- 7.3 Arrowhead
- 7.3.1 Arrowhead Profile
- 7.3.2 Arrowhead Main Business
- 7.3.3 Arrowhead RNAi for Therapeutic Products, Services and Solutions
- 7.3.4 Arrowhead RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.3.5 Arrowhead Recent Developments
- 7.4 Silence Therapeutics
- 7.4.1 Silence Therapeutics Profile
- 7.4.2 Silence Therapeutics Main Business
- 7.4.3 Silence Therapeutics RNAi for Therapeutic Products, Services and Solutions
- 7.4.4 Silence Therapeutics RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.4.5 Silence Therapeutics Recent Developments
- 7.5 Benitec Biopharma
- 7.5.1 Benitec Biopharma Profile
- 7.5.2 Benitec Biopharma Main Business
- 7.5.3 Benitec Biopharma RNAi for Therapeutic Products, Services and Solutions
- 7.5.4 Benitec Biopharma RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.5.5 Benitec Biopharma Recent Developments
- 7.6 Phio Pharmaceuticals
- 7.6.1 Phio Pharmaceuticals Profile
- 7.6.2 Phio Pharmaceuticals Main Business
- 7.6.3 Phio Pharmaceuticals RNAi for Therapeutic Products, Services and Solutions
- 7.6.4 Phio Pharmaceuticals RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.6.5 Phio Pharmaceuticals Recent Developments
- 7.7 RXi Pharmaceuticals
- 7.7.1 RXi Pharmaceuticals Profile
- 7.7.2 RXi Pharmaceuticals Main Business
- 7.7.3 RXi Pharmaceuticals RNAi for Therapeutic Products, Services and Solutions
- 7.7.4 RXi Pharmaceuticals RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.7.5 RXi Pharmaceuticals Recent Developments
- 7.8 Arrakis Therapeutics
- 7.8.1 Arrakis Therapeutics Profile
- 7.8.2 Arrakis Therapeutics Main Business
- 7.8.3 Arrakis Therapeutics RNAi for Therapeutic Products, Services and Solutions
- 7.8.4 Arrakis Therapeutics RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.8.5 Arrakis Therapeutics Recent Developments
- 7.9 Benitec Biopharma
- 7.9.1 Benitec Biopharma Profile
- 7.9.2 Benitec Biopharma Main Business
- 7.9.3 Benitec Biopharma RNAi for Therapeutic Products, Services and Solutions
- 7.9.4 Benitec Biopharma RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.9.5 Benitec Biopharma Recent Developments
- 7.10 miRagen Therapeutics
- 7.10.1 miRagen Therapeutics Profile
- 7.10.2 miRagen Therapeutics Main Business
- 7.10.3 miRagen Therapeutics RNAi for Therapeutic Products, Services and Solutions
- 7.10.4 miRagen Therapeutics RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.10.5 miRagen Therapeutics Recent Developments
- 7.11 Sylentis
- 7.11.1 Sylentis Profile
- 7.11.2 Sylentis Main Business
- 7.11.3 Sylentis RNAi for Therapeutic Products, Services and Solutions
- 7.11.4 Sylentis RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.11.5 Sylentis Recent Developments
- 7.12 Gradalis
- 7.12.1 Gradalis Profile
- 7.12.2 Gradalis Main Business
- 7.12.3 Gradalis RNAi for Therapeutic Products, Services and Solutions
- 7.12.4 Gradalis RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.12.5 Gradalis Recent Developments
- 7.13 Sirnaomics
- 7.13.1 Sirnaomics Profile
- 7.13.2 Sirnaomics Main Business
- 7.13.3 Sirnaomics RNAi for Therapeutic Products, Services and Solutions
- 7.13.4 Sirnaomics RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.13.5 Sirnaomics Recent Developments
- 7.14 Silenseed
- 7.14.1 Silenseed Profile
- 7.14.2 Silenseed Main Business
- 7.14.3 Silenseed RNAi for Therapeutic Products, Services and Solutions
- 7.14.4 Silenseed RNAi for Therapeutic Revenue (US$ Million) & (2020-2025)
- 7.14.5 Silenseed Recent Developments
8 Industry Chain Analysis
- 8.1 RNAi for Therapeutic Industrial Chain
- 8.2 RNAi for Therapeutic Upstream Analysis
- 8.2.1 Key Raw Materials
- 8.2.2 Raw Materials Key Suppliers
- 8.2.3 Manufacturing Cost Structure
- 8.3 Midstream Analysis
- 8.4 Downstream Analysis (Customers Analysis)
- 8.5 Sales Model and Sales Channels
- 8.5.1 RNAi for Therapeutic Sales Model
- 8.5.2 Sales Channel
- 8.5.3 RNAi for Therapeutic Distributors
9 Research Findings and Conclusion
10 Appendix
- 10.1 Research Methodology
- 10.1.1 Methodology/Research Approach
- 10.1.1.1 Research Programs/Design
- 10.1.1.2 Market Size Estimation
- 10.1.1.3 Market Breakdown and Data Triangulation
- 10.1.2 Data Source
- 10.1.2.1 Secondary Sources
- 10.1.2.2 Primary Sources
- 10.2 Author Details
- 10.3 Disclaimer