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原位杂合反应（ISH）市场规模、份额和成长分析（按产品、技术、应用、最终用户和地区划分）－2026-2033年产业预测

市场调查报告书

商品编码

1897192

原位杂合反应（ISH）市场规模、份额和成长分析（按产品、技术、应用、最终用户和地区划分）－2026-2033年产业预测

In Situ Hybridization ISH Market Size, Share, and Growth Analysis, By Product, By Technology, By Application, By End-User, By Region - Industry Forecast 2026-2033

出版日期: 2025年12月19日 | 出版商:

SkyQuest | 英文 278 Pages | 商品交期: 3-5个工作天内

价格

简介目录

全球原位杂合反应（ISH）市场规模预计在 2024 年达到 23.6 亿美元，从 2025 年的 26.6 亿美元增长到 2033 年的 68.2 亿美元，在预测期（2026-2033 年）内复合年增长率为 12.5%。

由于原位杂合反应(ISH) 在定位和分析各种生物样本中的核酸方面发挥着至关重要的作用，全球 ISH 市场正经历显着增长。这项先进的分子生物学技术能够揭示目标生物体内核酸的分布，从而支持分子诊断、基因编辑和重组 DNA 技术等重要应用。 ISH 的高灵敏度和精确定量能力使其成为免疫学、发育生物学和血液病理学等领域不可或缺的技术。其主要应用领域包括疾病预后诊断、药物发现和生物标记评估，进一步促进了研究活动。诸如邻近连接原位杂合反应(PLISHI) 等创新方法的出现，提高了 ISH 的性能和便利性，推动了这一充满活力的市场领域的广泛研发。

全球原位杂合反应（ISH）市场驱动因素

全球原位杂合反应(ISH) 市场受到各人群癌症病例不断增加的显着影响。大量研究表明，反覆出现的基因组异常是多种癌症发展的关键驱动因素。将包括 ISH 在内的细胞遗传学检测与 DNA FISH 和免疫组织化学等技术相结合，为研究人员提供了一套全面的工具包，以推进下一代诊断方法的发展。特别是，原位成像技术能够对 RNA 水平的基因表现进行详细分析，从而深入了解癌细胞与其周围微环境之间的动态关係。这种日益加深的认识，加上血友病等疾病发病率的上升，预计将推动 ISH 市场显着成长。

限制全球原位杂合反应（ISH）市场的因素

全球原位杂合反应(ISH) 市场面临许多可能阻碍收入成长的重大挑战。其中一个主要因素是短寿命萤光分子的固有局限性，这些分子会随时间推移降低讯号效率，使检测成为时间依赖性过程。此外，在核酸拷贝数低的样本中识别特定个体也存在困难，这限制了对治疗后微量残存疾病相关的不平衡易位和低克隆细胞的检测效果。另外，ISH 的敏感度低于免疫组织化学，虽然假阳性结果较少，但在 PCR 过程中更容易发生样本污染。这些因素共同导致该技术在低病原体负荷疾病诊断的应用日益减少。

全球原位杂合反应（ISH）市场趋势

由于旨在提高原位杂合反应（ISH）调查方法灵敏度的重大进步，全球ISH市场正经历动态变化。链置换扩增和分子信标等创新技术拓展了ISH的应用范围，使其能够检测各种生物样本中低浓度的核酸标靶。技术的快速发展使ISH成为研究和诊断病理学中不可或缺的工具，并促进了其在临床和检查室环境中的广泛应用。随着对精准分子诊断需求的不断增长，ISH市场持续发展，为核酸检测的准确性和效率树立了新的标准。

北美洲
- 美国
- 加拿大
欧洲
- 德国
- 西班牙
- 法国
- 英国
- 义大利
- 其他欧洲地区
亚太地区
- 中国
- 印度
- 日本
- 韩国
- 亚太其他地区
拉丁美洲
- 巴西
- 其他拉丁美洲地区
中东和非洲
- 海湾合作委员会国家
- 南非
- 其他中东和非洲地区

竞争资讯

前五大公司对比
主要企业的市场定位（2025 年）
主要市场参与者所采取的策略
近期市场趋势
公司市占率分析（2025 年）
主要企业公司简介
- 公司详情
- 产品系列分析
- 依业务板块进行公司股票分析
- 2023-2025年营收年比比较

主要企业简介

Abbott（US）
F. Hoffmann-La Roche AG（Switzerland）
Thermo Fisher Scientific Inc.（US）
Danaher（US）
Agilent Technologies, Inc.（US）
Biocare Medical, LLC（US）
Bio-Techne Corporation（US）
QIAGEN NV（Netherlands）
Merck KGaA（Germany）
PerkinElmer（US）
Enzo Biochem（US）
Bio-Rad Laboratories（US）
Abnova Corporation（Taiwan）
BioGenex Laboratories（US）
OpGen（US）
Bio SB（US）
Abcam（UK）
Zytomed Systems GmbH（Germany）
NeoGenomics Laboratories（US）
BioView（Israel）

结论与建议

简介目录

Product Code: SQSG35J2010

Global In Situ Hybridization ISH Market size was valued at USD 2.36 Billion in 2024 and is poised to grow from USD 2.66 Billion in 2025 to USD 6.82 Billion by 2033, growing at a CAGR of 12.5% during the forecast period (2026-2033).

The global market for In Situ Hybridization (ISH) is experiencing significant growth, driven by its critical role in localizing and analyzing nucleic acids across various biological samples. This advanced molecular biology technique supports vital applications in molecular diagnostics, gene editing, and recombinant DNA technology by revealing the distribution of nucleic acids within target organisms. High sensitivity and accurate quantification make ISH invaluable in fields like immunology, developmental biology, and hematopathology. Key applications include disease prognosis, drug discovery, and biomarker assessment, further enhancing research initiatives. Innovative methodologies, such as Proximity Ligation in Situ Hybridization, have emerged, highlighting advancements in technology that improve performance and usability while promoting extensive research and development efforts in this dynamic market landscape.

Top-down and bottom-up approaches were used to estimate and validate the size of the Global In Situ Hybridization ISH market and to estimate the size of various other dependent submarkets. The research methodology used to estimate the market size includes the following details: The key players in the market were identified through secondary research, and their market shares in the respective regions were determined through primary and secondary research. This entire procedure includes the study of the annual and financial reports of the top market players and extensive interviews for key insights from industry leaders such as CEOs, VPs, directors, and marketing executives. All percentage shares split, and breakdowns were determined using secondary sources and verified through Primary sources. All possible parameters that affect the markets covered in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data.

Global In Situ Hybridization ISH Market Segments Analysis

Global In Situ Hybridization ISH Market is segmented by Product, Technology, Application, End-User and region. Based on Product, the market is segmented into Consumables, Instruments andSoftware. Based on Technology, the market is segmented into Fluorescent In Situ Hybridization and Chromogenic in Situ Hybridization. Based on Application, the market is segmented into Cancer Diagnostics, Cytology, Infectious Disease Diagnostics, Neuroscience and Immunology. Based on End-User, the market is segmented into Hospitals and Diagnostic Laboratories and Academic & Research Institutes. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.

Driver of the Global In Situ Hybridization ISH Market

The global In Situ Hybridization (ISH) market is significantly influenced by the rising prevalence of cancer cases across various populations. Extensive research has revealed recurrent genomic abnormalities as key factors in the initiation and progression of numerous cancers. The integration of cytogenetic assays, including ISH, along with techniques like DNA FISH and immunohistochemistry, provides researchers with a comprehensive toolkit for advancing next-generation diagnostic methodologies. Notably, in situ imaging techniques enable the detailed examination of gene expression at the RNA level, offering valuable insights into the dynamic relationship between cancer cells and their surrounding microenvironment. This growing understanding, combined with the increasing incidence of conditions such as hemophilia, positions the ISH market for substantial growth.

Restraints in the Global In Situ Hybridization ISH Market

The Global In Situ Hybridization (ISH) market faces several significant challenges that may hinder revenue growth. One key factor is the inherent limitations of short-lived fluorophore molecules, which reduce signal efficacy over time and make detection a time-sensitive process. Furthermore, the technique struggles in identifying specific individuals in samples containing low nucleic acid copies, limiting its effectiveness in detecting unbalanced translocations and low clonal cells associated with minimal residual disease post-treatment. Additionally, ISH's sensitivity is lower compared to immunohistochemistry, leading to fewer false positives and increased instances of sample contamination during PCR. These factors collectively contribute to a decline in the technique's popularity for diagnosing diseases linked to low pathogen loads.

Market Trends of the Global In Situ Hybridization ISH Market

The Global In Situ Hybridization (ISH) market is witnessing a dynamic shift driven by significant advancements aimed at enhancing the sensitivity of ISH methodologies. Innovative technologies, such as strand displacement amplification and molecular beacons, are broadening the applicability of ISH, enabling the detection of low-abundance nucleic acid targets within various biological samples. This surge in technological progress is positioning ISH as an indispensable tool in both research and diagnostic pathology, fostering increased adoption across clinical and laboratory settings. As demand for precise molecular diagnostics rises, the ISH market continues to evolve, establishing new standards for accuracy and efficiency in nucleic acid detection.

Introduction

Objectives of the Study
Scope of the Report
Definitions

Research Methodology

Information Procurement
Secondary & Primary Data Methods
Market Size Estimation
Market Assumptions & Limitations

Executive Summary

Global Market Outlook
Supply & Demand Trend Analysis
Segmental Opportunity Analysis

Market Dynamics & Outlook

Market Overview
Market Size
Market Dynamics
- Drivers & Opportunities
- Restraints & Challenges
Porters Analysis
- Competitive rivalry
- Threat of substitute
- Bargaining power of buyers
- Threat of new entrants
- Bargaining power of suppliers

Key Market Insights

Key Success Factors
Degree of Competition
Top Investment Pockets
Market Ecosystem
Market Attractiveness Index, 2025
PESTEL Analysis
Macro-Economic Indicators
Value Chain Analysis
Pricing Analysis
Technology Analysis
Regulatory Analysis
Patent Analysis
Case Studies

Global In Situ Hybridization ISH Market Size by Product & CAGR (2026-2033)

Market Overview
Consumables
- Probes
- Kits & Reagents
- Accessories
Instruments
Software

Global In Situ Hybridization ISH Market Size by Technology & CAGR (2026-2033)

Market Overview
Fluorescent In Situ Hybridization
- DNA Fluorescent in Situ Hybridization
- RNA Fluorescent in Situ Hybridization
- PNA Fluorescent in Situ Hybridization
Chromogenic in Situ Hybridization

Global In Situ Hybridization ISH Market Size by Application & CAGR (2026-2033)

Market Overview
Cancer Diagnostics
Cytology
Infectious Disease Diagnostics
Neuroscience
Immunology

Global In Situ Hybridization ISH Market Size by End-User & CAGR (2026-2033)

Market Overview
Hospitals and Diagnostic Laboratories
Academic & Research Institutes

Global In Situ Hybridization ISH Market Size & CAGR (2026-2033)

North America (Product, Technology, Application, End-User)
- US
- Canada
Europe (Product, Technology, Application, End-User)
- Germany
- Spain
- France
- UK
- Italy
- Rest of Europe
Asia Pacific (Product, Technology, Application, End-User)
- China
- India
- Japan
- South Korea
- Rest of Asia-Pacific
Latin America (Product, Technology, Application, End-User)
- Brazil
- Rest of Latin America
Middle East & Africa (Product, Technology, Application, End-User)
- GCC Countries
- South Africa
- Rest of Middle East & Africa

Competitive Intelligence

Top 5 Player Comparison
Market Positioning of Key Players, 2025
Strategies Adopted by Key Market Players
Recent Developments in the Market
Company Market Share Analysis, 2025
Company Profiles of All Key Players
- Company Details
- Product Portfolio Analysis
- Company's Segmental Share Analysis
- Revenue Y-O-Y Comparison (2023-2025)

Key Company Profiles

Abbott (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
F. Hoffmann-La Roche AG (Switzerland)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Thermo Fisher Scientific Inc. (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Danaher (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Agilent Technologies, Inc. (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Biocare Medical, LLC (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Bio-Techne Corporation (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
QIAGEN N.V. (Netherlands)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Merck KGaA (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
PerkinElmer (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Enzo Biochem (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Bio-Rad Laboratories (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Abnova Corporation (Taiwan)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
BioGenex Laboratories (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
OpGen (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Bio SB (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Abcam (UK)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Zytomed Systems GmbH (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
NeoGenomics Laboratories (US)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
BioView (Israel)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments