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市场调查报告书
商品编码
1656921
原位杂交市场:全球洞察、竞争格局与 2032 年预测In Situ Hybridization - Market Insights, Competitive Landscape, and Market Forecast - 2032 |
到 2024 年,原位杂交市场规模预计将达到 16.7355 亿美元。预计预测期内(2025-2032 年),市场复合年增长率为 7.12%,到 2032 年将达到 28.8613 亿美元。原位杂交的需求大幅增加,主要原因是癌症和遗传疾病的发生率不断上升。此外,神经疾病和传染病的趋势也进一步推动了这项需求。除此之外,研发活动和资金的增加是推动原位杂交市场成长轨迹的关键因素。预计这一成长趋势将在 2025 年至 2032 年的整个预测期内持续并蓬勃发展。
ISH 用于诊断唐氏症和爱德华氏症等先天性疾病。研究可以分析特定基因在组织和器官中的表现方式,阐明它们在发育过程、疾病和生理功能中的作用。因此,患有遗传疾病和一些罕见疾病的人数不断增加,预计将促进市场的成长。例如,根据世界经济论坛2023年2月发布的报告,2019年约有4.75亿人患有罕见疾病,占世界人口的10%。未来五年内,预计约有 1,520 万人将接受专为识别罕见疾病而设计的临床基因组检测。
根据强生公司2023年2月发表的文章估计,截至2023年,全球将有超过3亿人患有罕见疾病。萤光原位杂交(FISH)是病理学家用来帮助诊断染色体异常引起的疾病的基因检测技术。因此,遗传疾病和罕见疾病的增加促进了原位杂交的广泛应用,预计这将推动市场成长。
根据世界卫生组织(WHO)2022年发布的数据,2020年全球报告乳癌约226万例、肺癌221万例、大肠直肠癌193万例、摄护腺癌141万例、胃癌109万例。
根据全球癌症观察站2021年发表的数据,2020年全球报告了约544,352例非何杰金氏淋巴瘤和83,087例霍奇金淋巴瘤。据同一消息来源称,2020 年全球报告了约 474,519 例白血病病例和约 176,404 例多发性骨髓瘤病例。原位杂交是研究癌症相关基因表现变化和染色体异常的有价值的工具,有助于发现潜在的诊断指标和治疗干预目标,从而推动市场成长。
爱滋病毒和肝炎等传染病的增加也是原位杂交 (ISH) 市场的主要驱动力。原位杂交 (ISH) 结合实验室医学和分子遗传技术来检测传染性病原体。萤光原位杂交 (FISH) 特别适用于在保持细胞结构完整性的同时识别和定位不同样本中的核甘酸序列。根据2022年世界卫生组织(WHO)的公告,预计2022年全球将有约3.54亿人感染B型肝炎或C型肝炎。
政府的支持和资助旨在最大限度地发挥罕见疾病伙伴关係的价值,其总体目标是提高罕见疾病领域的研究和创新水平。例如,2023 年 9 月,英国研究和创新部门将总投资约 7.985 亿美元(6.27 亿英镑),涵盖一系列旨在推进罕见疾病研究的措施。值得注意的是,2016 年至 2021 年期间,MRC 奖学金和 NIHR 职业发展奖已获得 1.269 亿美元(9,970 万英镑)的拨款,展现了围绕罕见疾病研究工作的全面支持网络。
本报告概述了全球原位杂交市场,包括按产品类型、技术、应用、最终用户、区域趋势和公司概况划分的市场概述。
In Situ Hybridization Market by Product Type (Instruments, Reagents & Kits, and Software), Technology (Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ Hybridization (CISH), and Others), Application (Cancer Diagnosis, Genetic Diseases, Infectious Diseases, and Others), End-User (Hospitals and Clinics, Diagnostic Centers, Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World) is expected to grow at a steady CAGR forecast till 2032 owing to the growing prevalence of cancer and genetic diseases and increasing incidences of neurological disorders and infectious disease
The in situ hybridization market was valued at USD 1,673.55 million in 2024, growing at a CAGR of 7.12% during the forecast period from 2025 to 2032 to reach USD 2,886.13 million by 2032. The demand for in situ hybridization is witnessing a notable surge, driven predominantly by the escalating prevalence of cancer and genetic diseases. Additionally, the upward trend in neurological disorders and infectious diseases further fuels this demand. Coupled with this, the intensifying R&D activities and funding are pivotal factors propelling the positive growth trajectory of the in situ hybridization market. This growth trend is expected to persist and flourish throughout the forecast period spanning from 2025 to 2032.
In Situ Hybridization Market Dynamics:
ISH is used to diagnose congenital diseases such as Down's syndrome and Edward's Syndrome. It enables researchers to analyze how certain genes are expressed in tissues or organs, shedding light on their involvement in developmental processes, diseases, and physiological functions. Therefore, the rising number of people affected by genetic or some kind of rare disease is expected to contribute to the growth of the market. For instance, a report by the World Economic Forum in February 2023, stated that approximately 475 million individuals were suffering from rare conditions in 2019 which comprised 10% of the global population. Within the upcoming five years, it was anticipated that around 15.2 million people were expected to undergo clinical genomic testing specifically aimed at identifying rare conditions.
According to an article shared by Johnson & Johnson in February 2023, the estimate suggests that over 300 million individuals were affected with rare diseases as of 2023 globally. Fluorescence in situ hybridization (FISH) is a genetic testing technique used by pathologists to aid in diagnosing diseases attributed to chromosomal abnormalities. Therefore, the growing genetic and rare diseases contribute to the extensive use of in situ hybridization which is expected to drive the market growth.
According to data cited by the World Health Organization in 2022, around 2.26 million cases of breast, 2.21 million cases of lung, 1.93 million cases of colon and rectum, 1.41 million cases of prostate, and 1.09 million cases of stomach cancer were reported in 2020 around the world.
As per data published by Global Cancer Observatory in 2021, around 544,352 cases of non-Hodgkin lymphoma and 83,087 cases of Hodgkin lymphoma were reported in 2020 worldwide. As per the same source, around 474,519 leukemia cases and nearly 176,404 cases of multiple myeloma were reported in 2020 across the globe. In situ hybridization serves as a valuable tool in examining changes in gene expression or chromosomal irregularities linked to cancer, aiding in the discovery of potential diagnostic indicators and targets for therapeutic intervention, thereby driving market growth.
The rising cases of infectious diseases such as HIV, hepatitis, and others is another key driver for the in situ hybridization (ISH) market. In situ hybridization (ISH) amalgamates laboratory medicine with molecular genetics technology to detect infectious pathogens. Fluorescence in situ hybridization (FISH) specifically aids in identifying and pinpointing nucleotide sequences within diverse samples, all while maintaining the integrity of cellular structures. According to the World Health Organization (WHO) 2022, it was estimated that around 354 million people were living with Hepatitis B or C infections in 2022 globally.
Government support and funding are directed towards maximizing the value derived from the Rare Diseases Partnership, with the overarching goal of fostering increased levels of research and innovation in the field of rare diseases. For instance, in September 2023, UK Research and Innovation, the investment, totaling nearly USD 798.5 million (GBP 627 million), encompasses various initiatives aimed at advancing rare disease research. Notably, USD 126.9 million (GBP 99.7 million) had been allocated to MRC fellowships and NIHR career development awards between 2016 and 2021, illustrating the comprehensive support network surrounding rare disease research efforts.
However, the in situ hybridization market may face growth constraints due to various factors, including the inefficiency of detecting DNA level rearrangements and chromosome pairs and concerns regarding potential exposure to radioactivity.
In Situ Hybridization Market Segment Analysis:
In Situ Hybridization Market by Product Type (Instruments, Reagents & Kits, and Software), Technology (Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ Hybridization (CISH), and Others), Application (Cancer Diagnosis, Genetic Diseases, Infectious Diseases, and Others), End-User (Hospitals and Clinics, Diagnostic Centers, Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World)
In the technology segment of the in situ hybridization market, the fluorescence in situ hybridization (FISH) category is estimated to account for a significant revenue share in the in situ hybridization market in 2024. This is attributed to the growing use of FISH in cancer diagnosis and research. In oncology, FISH is utilized to identify genetic changes linked with cancer, including gene amplifications, deletions, and rearrangements of chromosomes. Fluorescence in situ hybridization (FISH) is mainly used in the diagnosis, categorization, prognosis, and anticipation of treatment outcomes in cancer patients.
The application of FISH spans a broad spectrum of scientific disciplines, including genetic counseling, subcellular studies, detection and localization of chromosome mutations, species identification, biomedical research, clinical diagnosis, toxicology, chromosomal biology, and comparative genomics.
Key players in the market are developing innovative kits and reagents for fluorescence in situ hybridization (FISH) procedures. For instance, in December 2021, BioGenex, a US-based molecular pathology company launched NanoVIP. NanoVIP is a compact, fully automated bench-top system equipped with visualization kits designed for fluorescence in situ hybridization (FISH) and in-situ hybridization (ISH). Its 10-slide design ensures reliability through automation, featuring eXACT(TM) temperature control modules for individual slide positions, precise management of reaction times, and liquid level sensors for accurate liquid handling. This meticulous control ensures the delivery of clean, intense, reliable, and reproducible stains, minimizing the need for repeat procedures.
Further, in cellular biology and neuroscience, scientists utilize techniques such as fluorescence in situ hybridization (FISH) to investigate the expression, localization, and dynamics of genes within cells and tissues. This method allows for the visualization of specific genes or RNA molecules in various cell types including neuronal cells, glial cells, and others. By studying gene expression patterns and their spatial distribution, researchers gain valuable insights into brain function, development, and the underlying mechanisms of neurological disorders. Additionally, FISH can aid in the diagnosis of genetic disorders by enabling the visualization of specific chromosomal regions or genes associated with these conditions. Therefore, the wide applications of the fluorescence in situ hybridization (FISH) category is expected to contribute to the growth of the segment, thereby driving the growth of the in situ hybridization market during the forecast period.
North America is expected to dominate the Overall In-Situ Hybridization Market:
North America is estimated to dominate the in situ hybridization market in 2024. This is attributed to the growing prevalence of cancer and rare genetic diseases. In situ hybridization (ISH) stands as a pivotal tool in cancer research and diagnosis, facilitating the detection of gene expression and genetic abnormalities linked with cancer. These capabilities significantly contribute to the growth of the market in the region. Moreover, the escalating number of molecular diagnostics tests conducted in the region further propels the expansion of the North America in situ hybridization market.
Fluorescence in situ hybridization (FISH) is a diagnostic test that maps the genetic material within human cells, pinpointing specific genes or gene segments. Due to its capability to detect genetic abnormalities linked to cancer, FISH serves as a valuable tool in diagnosing certain types of the disease. For instance, according to the National Cancer Institute 2020, it was estimated that around 1,806,590 cancer cases were diagnosed in the year 2020 in the United States.
According to the Centers for Disease Control and Prevention (CDC) in May 2024, approximately 5,700 babies were born with Down syndrome each year in the United States. This equates to a prevalence of about 1 in every 640 babies. In situ hybridization is used to identify an extra chromosome or an extra piece of a chromosome for diagnosis of Down syndrome. Therefore, the growing prevalence of rare and genetic diseases is expected to drive the market growth in the region.
In Situ Hybridization Market Key Players:
Some of the key market players operating in the in situ hybridization market include Abbott Laboratories, Agilent Technologies, Inc., Thermo Fisher Scientific Inc., F. Hoffmann-La Roche Ltd, Merck & Co., Inc., PerkinElmer Inc., Sysmex Corporation, Biocare Medical, LLC, Genemed Biotechnologies, Inc., NeoGenomics Laboratories, Advanced Cell Diagnostics, Inc., BioView, Bio-Rad Laboratories, Inc., Bio-Techne, QIAGEN, BioGenex, ZYTOVISION GmbH, Promega Corporation, Illumina, Inc., Danaher Corporation, and others.
Recent Developmental Activities in the In-Situ Hybridization Market:
Key Takeaways from the In Situ Hybridization Market Report Study
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FREQUENTLY ASKED QUESTIONS FOR THE IN SITU HYBRIDIZATION MARKET: