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									 市场调查报告书 
										商品编码 
											1828133 
										2025年原位杂合反应全球市场报告In Situ Hybridization Global Market Report 2025 | 
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近年来,原位杂合反应市场呈现强劲成长势头,市场规模从2024年的16.8亿美元成长至2025年的18.1亿美元,复合年增长率达8.1%。这段时期的成长可归因于早期研究的采用、分子生物学工具的不断发展、诊断应用的开发、生物医学研究重点的转变以及生物技术投资的不断增加。
预计未来几年原位杂合反应市场规模将快速成长,到2029年将达到27.6亿美元,复合年增长率为11.1%。预测期内的成长可归因于临床诊断应用的不断增长、研发资金的增加、自动化和高通量解决方案的出现,以及在神经科学和病理学领域应用的不断拓展。预测期内的主要趋势包括分子生物学的进步、研究应用需求的不断增长、诊断应用的不断拓展、个人化医疗的需求以及生物医学研究资金的不断增加。
原位杂合反应是一种能够精确定位组织切片中特定核酸片段的技术。此技术可用于识别组织(包括完整组织、组织切片和单一细胞)中的核苷酸序列。
原位杂合反应产品的主要类型包括分析仪器、套件和试剂以及软体和服务。分析仪器旨在帮助研究人员检测和可视化细胞和组织内的特定核酸序列。此过程涉及的各种技术包括萤光原位杂合反应(FISH) 和显色原位杂合反应(CISH),它们使用不同类型的探针,例如 DNA 和 RNA。这些技术应用于各个领域,包括癌症研究、细胞遗传学、发育生物学和感染疾病。这些产品的最终用户包括研究和诊断实验室、受託研究机构(CRO) 和学术机构。
2025年春季美国关税的突然上调及其引发的贸易摩擦对医疗设备行业产生了重大影响,尤其对用于诊断影像设备的进口零件、手术用不銹钢和一次性塑胶製品产生了重大影响。由于医院和诊所抵制涨价,製造商面临利润压力。监管挑战使情况更加复杂,因为由于关税而更换供应商通常需要重新认证医疗设备,导致市场进入延迟。为此,企业正在透过双重采购关键零件、增加标准化产品的国内生产以及加快寻找更具成本效益的材料来降低风险。
本研究报告是商业研究公司 (The Business Research Company) 新报告系列的一部分,该系列提供原位杂合反应市场统计数据,例如原位杂合反应行业的全球市场规模、各地区市场份额、杂合反应的市场份额、原位杂合反应市场细分、市场趋势和机会,以及您在原位杂合反应行业取得成功所需的数据。本原位杂合反应市场研究报告对该行业的现状和未来趋势进行了详细分析,为您提供所需的一切观点。
未来五年11.1%的预测成长率比我们先前对该市场的预测略有下降,下降了0.1%。这一下降主要源自于美国与其他国家之间关税的影响。这可能会透过对来自日本和瑞士等主要地区的萤光去氧核糖核酸(DNA) 探针和自动染色平台征收关税直接影响美国,从而导致基因检测结果延迟,并增加癌症和遗传疾病诊断的成本。由于互惠关税以及不断升级的贸易摩擦和限制对全球经济和贸易的负面影响,其影响将更加广泛。
预计感染疾病的增加将在未来几年推动原位杂合反应市场的成长。感染疾病是一种病理状况,可透过病毒、细菌、真菌和寄生虫等病原体以及受污染的食物和饮料在人与人之间传播。原位杂合反应(ISH) 使用特异性传染性生物的标记核酸序列(探针)来检测组织样本中的互补核酸序列。因此,感染疾病的增加促进了原位杂合反应市场的扩张。例如,2024 年 3 月,美国政府机构疾病管制与预防中心 (CDC) 报告称,结核病患者人数从 2022 年的 8,320 人增加了 1,295 人,到 2023 年则增加了 9,615 人。因此,感染疾病的日益普及正在推动原位杂合反应市场的成长。
癌症患者数量的快速成长预计将推动原位杂合反应市场的成长。原位杂合反应用于识别癌细胞中的特定基因变异,例如基因扩增、缺失、易位和重排。根据美国癌症协会 (ACS) 的数据,2023 年美国将新增 1,958,310 例癌症病例,并有 609,820 例癌症死亡病例。因此,癌症发生率的上升是推动原位杂合反应市场成长的关键因素。
原位杂合反应市场的主要企业正致力于创造创新解决方案,例如 RNA 检测分析,以促进基因疗法的发展。 RNA 检测分析是一种分子技术,旨在识别和量化样本中的特定 RNA 分子,使研究人员能够研究基因表现、病毒感染和各种与 RNA 相关的生物过程。例如,2023 年 1 月,美国生命科学公司 Bio-Techne Corporation 推出了 RNAscope Plus smRNA-RNA 检测分析。这种先进的原位杂合反应工具能够同时萤光检测同一组织切片中的三种目标 RNA 或 RNA 生物标记物以及调节性小 RNA,包括微型RNA (miRNA)。此检测提供单细胞和亚细胞分辨率,使研究人员能够有效评估新型基因疗法和内源性调节 RNA 的生物分布和功能。此检测具有可扩展性,可支援大规模研究,可在 Leica Bond Rx 平台上使用,也可作为手动检测。结合我们专有的 RNAscope 和 miRNAscope 技术,该检测显着增强了我们对基因表现和细胞反应的理解,为开发针对遗传和后天性疾病的个人化基因疗法提供了重要的见解。
原位杂合反应市场的主要企业正透过创新产品解决方案提升盈利,例如杂交炼式反应RNA显色原位杂合反应(HCR RNA-CISH)。 HCR RNA-CISH是一种高解析度和高灵敏度可视化细胞和组织中RNA分子的技术。 2023年2月,Molecular Instruments (MI) 推出了HCR RNA-CISH,增强了自动化显色原位杂合反应工作流程。它还原生支援免疫组织化学(IHC)程式码检测,并与主流自动化平台完全相容。
2023年1月,美国生命科学公司安捷伦科技公司(Agilent Technologies Inc.)收购了Avida Biomed Inc.,收购金额未揭露。此次收购旨在增强安捷伦在基因组学领域的能力,并扩展其为研究人员提供的创新工具范围,尤其是在下一代定序和生物分子分析领域。 Avida Biomed是一家总部位于美国的生物技术公司,专注于开髮用于各种医疗应用的尖端诊断解决方案和检测方法。
原位杂合反应市场的主要企业包括 Thermo Fisher Scientific Inc.、Bio SB Inc.、BioGenex Laboratories、Advanced Cell Diagnostics Inc.、Exiqon A/S、Agilent Technologies Inc.、F. Hoffmann-La Roche AG、Abbott Laboratories Inc.、Merck KGaA、Perkind LLC.S. Nussloch GmbH、Bio-Rad Laboratories Inc.、Oxford Gene Technology、Abnova Corporation、Qiagen、Bio-Techne Corporation、Biochain Institute Inc.、Cytocell Ltd.、Enzo Life Sciences Inc.、Eurofins Scientific SE、FISH Technologies Sdn Bhd 和 Gene Biotech Asia Pvt。 Ltd.、Zytomed System GmbH、Akoya Biosciences Inc.、Becton Dickinson and Company (BD)、DAKO Systemtechnik und Service GmbH GmbH & Co、Molecular Devices LLC.、NanoString Technologies Inc. 与 Visiopharm A/S。
2024年,北美是原位杂合反应市场最大的地区。预计预测期内,亚太地区将成为全球原位杂合反应市场成长最快的地区。原位杂合反应市场报告涵盖的地区包括亚太地区、西欧、中欧和东欧、北美、南美以及中东和非洲。
原位杂合反应市场报告涵盖的国家:澳洲、巴西、中国、法国、德国、印度、印尼、日本、俄罗斯、韩国、英国、美国、加拿大、义大利、西班牙
原位杂合反应市场包括使用合成寡核苷酸探针、双链DNA (dsDNA)探针和单链DNA (dsDNA)探针提供原位杂合反应的营业单位所获得的收益。市场规模还包括服务供应商销售或包含在其服务产品中的相关产品的价值。原位杂合反应市场还包括线性杂合反应炼式反应和非线性杂合反应炼式反应技术的销售。该市场的价值是指“出厂价”,即产品製造商或创造者销售给其他营业单位(包括下游製造商、批发商、经销商和零售商)或直接销售给最终客户的产品价值。该市场中的产品价值还包括产品创造者销售的任何相关服务。
In-situ hybridization is a method that facilitates the precise localization of a specific nucleic acid segment within a histologic slice. This technique is employed for identifying sequences of nucleotides in tissues, encompassing complete tissues, portions of tissues, and individual cells.
The primary types of in-situ hybridization products include analytical instruments, kits and reagents, software and services, among others. Analytical instruments are designed to assist researchers in detecting and visualizing specific nucleic acid sequences within cells or tissues. Various techniques involved in this process include fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH), which utilize different types of probes such as DNA and RNA. These techniques find applications in diverse areas, including cancer research, cytogenetics, developmental biology, infectious diseases, and more. The end users of these products include research and diagnostic laboratories, contract research organizations (CROs), academic institutes, and others.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sharp increase in U.S. tariffs and resulting trade tensions in spring 2025 are significantly impacting the medical equipment sector, especially for imported components used in imaging machines, surgical-grade stainless steel, and disposable plastics. With hospitals and clinics pushing back against price increases, manufacturers are facing margin pressure. The situation is further complicated by regulatory challenges, as switching suppliers due to tariffs often necessitates re-certification of medical devices, leading to delays in market entry. In response, companies are mitigating risks by dual-sourcing key components, ramping up domestic production of standardized items, and accelerating research into more cost-effective materials.
The in situ hybridization market research report is one of a series of new reports from The Business Research Company that provides in situ hybridization market statistics, including in situ hybridization industry global market size, regional shares, competitors with an in situ hybridization market share, detailed in situ hybridization market segments, market trends and opportunities, and any further data you may need to thrive in the in situ hybridization industry. This in situ hybridization market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The in situ hybridization market size has grown strongly in recent years. It will grow from $1.68 billion in 2024 to $1.81 billion in 2025 at a compound annual growth rate (CAGR) of 8.1%. The growth in the historic period can be attributed to early adoption in research, evolution of molecular biology tools, diagnostic applications development, shift in biomedical research focus, increasing investment in biotechnology.
The in situ hybridization market size is expected to see rapid growth in the next few years. It will grow to $2.76 billion in 2029 at a compound annual growth rate (CAGR) of 11.1%. The growth in the forecast period can be attributed to increasing adoption in clinical diagnostics, growth in research and development funding, automation and high-throughput solutions, expanded applications in neuroscience and pathology. Major trends in the forecast period include advancements in molecular biology, rising demand in research applications, diagnostic applications expansion, demand for personalized medicine, increased funding in biomedical research.
The forecast of 11.1% growth over the next five years indicates a slight reduction of 0.1% from the previous estimate for this market.This reduction is primarily due to the impact of tariffs between the US and other countries. This is likely to directly affect the US through tariffs on fluorescent deoxyribonucleic acid (DNA) probes and automated staining platforms, sourced from key regions such as Japan and Switzerland, which could lead to delayed genetic testing results and increased costs for cancer and genetic disorder diagnostics.The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.
The rise in infectious diseases is projected to drive the growth of the in-situ hybridization market in the coming years. Infectious diseases are conditions that can be transmitted from one person to another through contaminated food and beverages, as well as through pathogens such as viruses, bacteria, fungi, and parasites. In situ hybridization (ISH) aims to detect complementary nucleic acid sequences in tissue samples by using labeled nucleic acid sequences (probes) that are specific to the infectious organism. Thus, a rise in infectious diseases contributes to the expansion of the in-situ hybridization market. For example, in March 2024, the Centers for Disease Control and Prevention (CDC), a U.S.-based government agency, reported that tuberculosis cases increased from 8,320 in 2022 to 9,615 in 2023, representing a rise of 1,295 cases. Therefore, the growing prevalence of infectious diseases is fueling the growth of the in-situ hybridization market.
The upsurge in cancer cases is anticipated to fuel the growth of the in-situ hybridization market. In-situ hybridization is employed to identify specific genetic alterations in cancer cells, including gene amplifications, deletions, translocations, and rearrangements. According to the American Cancer Society (ACS), it is projected that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. Hence, the increasing incidence of cancer is a significant factor contributing to the growth of the in-situ hybridization market.
Key players in the in situ hybridization market are concentrating on creating innovative solutions, such as RNA detection assays, to enhance the development of gene therapies. An RNA detection assay is a molecular technique designed to identify and quantify specific RNA molecules within a sample, allowing for the examination of gene expression, viral infections, and various RNA-related biological processes. For example, in January 2023, Bio-Techne Corporation, a life sciences company based in the U.S., introduced the RNAscope Plus smRNA-RNA detection assay. This advanced in situ hybridization tool enables the simultaneous fluorescent detection of small regulatory RNAs, including microRNAs (miRNAs), alongside three target RNAs or RNA biomarkers within the same tissue section. The assay offers single-cell and subcellular resolution, allowing researchers to evaluate the biodistribution and functionality of novel gene therapies and endogenous regulatory RNAs effectively. It is designed for scalability to support large-scale studies and can be used on the Leica Bond Rx platform or as a manual assay. By combining proprietary RNAscope and miRNAscope technologies, this assay significantly enhances the understanding of gene expression and cellular responses, providing essential insights for the development of personalized gene therapies for both inherited and acquired diseases.
Major companies operating in the in-situ hybridization market are driving profitability through innovative product solutions, such as Hybridization Chain Reaction RNA Chromogenic in situ Hybridization (HCR RNA-CISH). HCR RNA-CISH is a technique that facilitates the visualization of RNA molecules in cells and tissues with high resolution and sensitivity. In February 2023, Molecular Instruments (MI) launched HCR RNA-CISH to enhance automated chromogenic in-situ hybridization workflows, providing better performance than existing approaches with reduced turnaround time and cost. It also features native support for Immunohistochemistry (IHC) codetection and full compatibility with major automation platforms.
In January 2023, Agilent Technologies Inc., a life sciences company based in the U.S., acquired Avida Biomed Inc. for an undisclosed sum. This acquisition is intended to bolster Agilent's capabilities in genomics and broaden its range of innovative tools for researchers, especially in next-generation sequencing and biomolecular analysis. Avida Biomed Inc. is a U.S.-based biotechnology firm that focuses on creating cutting-edge diagnostic solutions and assays for a variety of medical applications.
Major companies operating in the in situ hybridization market include Thermo Fisher Scientific Inc., Bio SB Inc., BioGenex Laboratories, Advanced Cell Diagnostics Inc., Exiqon A/S, Agilent Technologies Inc., F. Hoffmann-La Roche AG, Abbott Laboratories Inc., Merck KGaA, PerkinElmer Inc., Biocare Medical LLC, Genemed Biotechnologies, Danaher Corporation, Leica Biosystems Nussloch GmbH, Bio-Rad Laboratories Inc., Oxford Gene Technology, Abnova Corporation, Qiagen, Bio-Techne Corporation, Biochain Institute Inc., Cytocell Ltd., Enzo Life Sciences Inc., Eurofins Scientific SE, FISH Technologies Sdn Bhd, Genetix Biotech Asia Pvt. Ltd., Zytomed System GmbH, Akoya Biosciences Inc., Becton Dickinson and Company (BD), DAKO Systemtechnik und Service GmbH & Co, Molecular Devices LLC., NanoString Technologies Inc., Visiopharm A/S
North America was the largest region in the in situ hybridization market in 2024. Asia-Pacific is expected to be the fastest-growing region in the global in situ hybridization market duirng the forecast period. The regions covered in the in situ hybridization market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa
The countries covered in the in situ hybridization market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain
The In-situ hybridization market includes revenues earned by entities by providing in-situ hybridization with synthetic oligonucleotides probes, double-stranded DNA (dsDNA) probes, and single-stranded DNA (dsDNA) probes. The market value includes the value of related goods sold by the service provider or included within the service offering. The In-situ hybridization market also includes sales of linear hybridization chain reaction techniques and non-linear hybridization chain reaction techniques. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
In Situ Hybridization Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on in situ hybridization market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for in situ hybridization ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The in situ hybridization market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.