市场调查报告书
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1551334
到 2030 年抗治疗性忧郁症市场预测:按治疗方式、分销管道、最终用户和地区进行的全球分析Treatment-Resistant Depression Market Forecasts to 2030 - Global Analysis by Treatment Modality, Distribution Channel, End User and By Geography |
根据 Stratistics MRC 的数据,2024 年全球抗治疗性忧郁症市场规模为 21 亿美元,预计预测期内复合年增长率为 11.8%,到 2030 年将达到 41 亿美元。
抗治疗性忧郁症(TRD) 是重度忧郁症的一种形式,对至少两种足够剂量和持续时间的抗忧郁症治疗没有充分反应。约有30%的忧郁症患者受到影响。 TRD 的特点是儘管采取了标准干预措施,但仍存在持续的忧郁症状,并且通常需要替代策略,例如药物、心理治疗、脑刺激技术和新疗法的组合。 TRD 对患者和临床医生来说是一个重大挑战,与非持久性忧郁症相比,它会导致功能障碍增加、医疗保健费用增加以及自杀行为的风险增加。
根据 2024 年 5 月发表在《美国精神病学杂誌》上的研究资料,美国接受药物治疗的重度忧郁症(MDD) 12 个月盛行率估计为 890 万人。
忧郁症盛行率增加
全球忧郁症盛行率的增加是抗治疗性忧郁症市场的主要驱动因素。根据世界卫生组织 (WHO) 统计,全球有超过 3 亿人患有忧郁症。随着忧郁症患者数量的增加,抗治疗性忧郁症患者的数量也增加。患者数量的增加为先进治疗方法创造了更大的市场,并推动了研究和开发,以找到针对这种困难疾病的更有效的治疗方法。
昂贵的治疗费用
抗治疗性忧郁症的高昂治疗费用是市场成长的主要限制因素。氯胺酮输注、经颅磁刺激和esketamine滴鼻剂等较新的治疗方法价格昂贵,而且通常不在保险范围内。例如,氯胺酮输註一个疗程可能花费数千美元。这些高昂的自付费用可能会限制许多患者获得治疗,阻碍新治疗方法的采用,并减缓市场扩张。
新疗法的研发管线
一系列针对抗治疗性忧郁症的新疗法提供了巨大的市场机会。几种有前景的化合物正处于后期临床试验中,包括裸盖菇素等致幻药物、新型麸胺酸促效剂和创新药物组合。例如,COMP360(裸盖菇素疗法)在 2 期试验中显示出正面的结果。如果这些新疗法有可能获得核准,我们可以透过扩大治疗选择、改善治疗结果和解决抗治疗性患者未满足的需求来预期市场成长。
严格的法规环境
FDA 等监管机构在核准新药,特别是具有新颖作用机制的核准时,需要大量的临床试验资料和安全性资料。这个严格的过程导致新药上市的延迟、开发成本的增加以及潜在的失败。监管障碍可能会抑制对创新治疗方法的投资,并减缓新治疗方法的推出速度。
COVID-19 大流行抗治疗性忧郁症市场产生了重大影响。禁闭和社会隔离导致忧郁症和焦虑增加,病例数可能还会增加。同时,医疗保健取得和临床试验的中断正在影响治疗提供和研究进展。然而,大流行加速了远端医疗和数位心理健康解决方案的采用,为治疗提供和市场成长开闢了新途径。
零售药房业务预计将在预测期内成为最大的业务
预计零售药房领域将在预测期内主导抗治疗性忧郁症市场。零售药局为抗治疗性忧郁症患者提供便利的处方药取得途径。零售药局在配药、病患教育和药物依从性支持方面发挥重要作用。透过零售管道越来越多地获得新型抗忧郁症和辅助性治疗,促进了这一领域的成长。此外,忧郁症门诊治疗的趋势和全球零售药局连锁店的增加进一步支持了这一领域的扩张。
神经刺激治疗领域预计在预测期内复合年增长率最高
在抗治疗性忧郁症市场中,神经刺激疗法预计将具有最高的复合年增长率。这种增长是由越来越多地采用非侵入性脑刺激技术(例如经颅磁刺激(TMS)和电休克治疗(ECT))所推动的。这些方法为对传统药物治疗没有反应的患者提供了替代治疗选择。越来越多的证据支持神经刺激的有效性以及提高安全性和耐受性的技术进步正在促进这一领域的快速扩张。
预计北美地区将在预测期内主导抗治疗性忧郁症市场。北美的优势归因于忧郁症盛行率较高、医疗基础设施完善以及较早采用新治疗方法等因素。该地区还受益于大量的研发投资、主要市场参与者的存在以及优惠的报销政策。此外,人们对心理健康的认识不断提高,对创新治疗方法的接受度也不断提高,这也有助于北美市场的领先地位。
在预测期内,亚太地区抗治疗性忧郁症市场预计将快速成长。这一增长是由心理健康意识增强、医疗基础设施改善和医疗支出增加等因素所推动的。中国和印度等国家人口众多,忧郁症盛行率不断上升,因此存在巨大的市场机会。此外,製药公司向亚太地区的扩张以及政府不断采取的解决心理健康问题的措施也促进了亚太市场的快速成长。
According to Stratistics MRC, the Global Treatment-Resistant Depression Market is accounted for $2.1 billion in 2024 and is expected to reach $4.1 billion by 2030 growing at a CAGR of 11.8% during the forecast period. Treatment-resistant depression (TRD) is a form of major depressive disorder that does not respond adequately to at least two different antidepressant treatments of sufficient dose and duration. It affects approximately 30% of people with depression. TRD is characterized by persistent depressive symptoms despite standard interventions, often requiring alternative strategies like medication combinations, psychotherapy, brain stimulation techniques, or novel therapies. It poses significant challenges for patients and clinicians, leading to increased functional impairment, higher healthcare costs, and a greater risk of suicidal behavior compared to non-resistant depression.
According to data from a study published in the American Journal of Psychiatry in May 2024, the estimated 12-month prevalence of medication-treated major depressive disorder (MDD) in the United States was 8.9 million adults.
Increasing prevalence of depression
The rising prevalence of depression globally is a key driver for the treatment-resistant depression market. According to the World Health Organization, over 300 million people suffer from depression worldwide. As the number of depression cases increases, so does the subset of patients with treatment-resistant depression. This growing patient pool creates a larger market for advanced therapies and drives research and development efforts to find more effective treatments for this challenging condition.
High cost of treatment
The high cost of treatment for treatment-resistant depression poses a significant restraint on market growth. Novel therapies like ketamine infusions, transcranial magnetic stimulation, and esketamine nasal sprays are expensive and often not covered by insurance. For example, a course of ketamine infusions can cost thousands of dollars. These high out-of-pocket costs limit access to treatment for many patients and hinder widespread adoption of newer therapies, potentially slowing market expansion.
Pipeline of novel therapies
The robust pipeline of novel therapies for treatment-resistant depression presents a significant market opportunity. Several promising compounds are in late-stage clinical trials, including psychedelics like psilocybin, new glutamatergic agents, and innovative drug combinations. For instance, COMP360 (psilocybin therapy) has shown positive results in phase 2 trials. The potential approval of these novel treatments could expand treatment options, improve outcomes, and drive market growth by addressing the unmet needs of treatment-resistant patients.
Stringent regulatory environment
Regulatory agencies like the FDA require extensive clinical trial data and safety profiles for new drug approvals, especially for novel mechanisms of action. This rigorous process can lead to delays, increased development costs, and potential failures in bringing new treatments to market. The regulatory hurdles may discourage investment in innovative therapies and slow the pace of new treatment options becoming available.
The COVID-19 pandemic has significantly impacted the treatment-resistant depression market. Lockdowns and social isolation have led to increased rates of depression and anxiety, potentially expanding the patient pool. Simultaneously, disruptions in healthcare access and clinical trials have affected treatment delivery and research progress. However, the pandemic has also accelerated the adoption of telemedicine and digital mental health solutions, opening new avenues for treatment delivery and market growth.
The retail pharmacies segment is expected to be the largest during the forecast period
The retail pharmacies segment is projected to dominate the treatment-resistant depression market during the forecast period. Retail pharmacies offer convenient access to prescription medications for patients with treatment-resistant depression. They play a crucial role in medication dispensing, patient education, and adherence support. The increasing availability of novel antidepressants and adjunctive therapies through retail channels contributes to this segment's growth. Additionally, the trend towards outpatient management of depression and the rising number of retail pharmacy chains globally further drive the expansion of this segment.
The neurostimulation segment is expected to have the highest CAGR during the forecast period
The neurostimulation segment is anticipated to experience the highest CAGR in the treatment-resistant depression market. This growth is driven by the increasing adoption of non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). These methods offer alternative treatment options for patients who have not responded to traditional pharmacotherapy. The growing body of evidence supporting the efficacy of neurostimulation techniques, coupled with technological advancements improving their safety and tolerability, contributes to the rapid expansion of this segment.
During the forecast period, the North American region is expected to dominate the treatment-resistant depression market. North America's dominance can be attributed to factors such as the high prevalence of depression, well-established healthcare infrastructure, and early adoption of novel therapies. The region also benefits from significant research and development investments, the presence of key market players, and favorable reimbursement policies. Additionally, increased awareness about mental health and growing acceptance of innovative treatments contribute to North America's leading position in the market.
During the forecast period, the Asia Pacific region is expected to witness rapid growth in the treatment-resistant depression market. This growth is driven by factors such as increasing awareness about mental health, improving healthcare infrastructure, and rising healthcare expenditure. The large population base and growing prevalence of depression in countries like China and India present significant market opportunities. Additionally, the expansion of pharmaceutical companies into the region and increasing government initiatives to address mental health issues contribute to the rapid market growth in Asia Pacific.
Key players in the market
Some of the key players in Treatment-Resistant Depression market include AstraZeneca, Pfizer Inc., GlaxoSmithKline plc, Eli Lilly and Company, Johnson & Johnson, Bristol-Myers Squibb Company, Forest Laboratories, Vistagen Therapeutics, Inc., Novartis, AbbVie Inc., H. Lundbeck A/S, Sandoz International GmbH, Otsuka Pharmaceutical Co., Ltd., Par Pharmaceutical, Mylan N.V., Aurobindo Pharma, and Teva Pharmaceutical Industries Ltd.
In August 2024, AbbVie announced that it has completed its acquisition of Cerevel Therapeutics. With the completion of the acquisition, Cerevel is now part of AbbVie. "AbbVie's acquisition of Cerevel strengthens our foundation in neuroscience and positions us to deliver sustainable long-term performance into the next decade and beyond," said Robert A. Michael, chief executive officer, AbbVie.
In July 2024, Johnson & Johnson announced the submission of a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking approval of SPRAVATO(R) (esketamine) CIII nasal spray as a monotherapy for adults living with treatment-resistant depression (TRD). Nearly 30 percent of the estimated 280 million people worldwide living with major depressive disorder (MDD) have TRD,1 which occurs when there is an inadequate response to two or more oral antidepressants during the same depressive episode.
In December 2022, AbbVie announced that the U.S. Food and Drug Administration (FDA) has approved VRAYLAR(R) (cariprazine) as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults. Supported by clinical data demonstrating efficacy and well-established tolerability, this additional indication provides a new option for adults who have a partial response to the treatment of an antidepressant.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.