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市场调查报告书
商品编码
1856968
全球神经退化性疾病市场:预测至 2032 年—按分子类型、适应症、药物类别、给药途径、最终使用者和地区进行分析Neurodegenerative Disease Market Forecasts to 2032 - Global Analysis By Molecule Type (Small-Molecule Drugs, Biologics and Cell & Gene Therapies), Indication, Drug Class, Route of Administration, End User and By Geography |
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根据 Stratistics MRC 的数据,预计到 2025 年,全球神经退化性疾病市场规模将达到 644 亿美元,到 2032 年将达到 1,189 亿美元,预测期内复合年增长率为 9.15%。
神经退化性疾病是指一组以神经细胞结构和功能逐渐丧失为特征的疾病,最终导致神经细胞逐渐死亡。这些疾病会影响大脑和神经系统,损害认知、运动和感觉功能。常见的例子包括阿兹海默症、帕金森氏症、亨廷顿氏症和肌萎缩性侧索硬化症(ALS)。其根本原因通常涉及异常蛋白质累积、基因突变、氧化压力和粒线体功能障碍。由于神经细胞无法有效再生,这些疾病通常会发展为慢性病,并随着时间的推移而恶化。由于其复杂性和缺乏有效治疗方法,神经退化性疾病为医学和社会带来了重大挑战。
生物标记和诊断技术的进步
研究人员正在开发体液和影像生物标记,以识别阿兹海默症、帕金森氏症和肌萎缩侧索硬化症(ALS)的早期病理。人工智慧和机器学习的结合正在提高诊断准确性和疾病分层能力。製药公司正在利用生物标记来优化试验设计和治疗标靶。伴随诊断在精准神经病学研发管线中正变得越来越普遍。这些能力正在推动早期疗育和个人化医疗领域的创新。
复杂疾病生物学与异质性
许多疾病的病因复杂,涉及遗传、环境和发炎等多种因素。疾病进展在个体间差异很大,这使得临床试验终点和治疗效果的评估变得复杂。临床前研究因缺乏经过验证的动物模型和转化生物标记而受阻。监管机构要求提供在异质人群中疗效和安全性的有力证据。这些挑战持续阻碍药物研发和平台规模化应用。
医疗保健支出和意识不断提高
各国政府正在资助国家失智症战略和老化相关研究计画。旨在消除认知衰退和神经系统疾病污名化的宣传活动正在进行中。医院正在扩大记忆诊所和神经復健中心,以满足日益增长的需求。对数位医疗和远端监测的投资正在支持长期护理和疾病管理。这些趋势正在推动预防、诊断和治疗创新领域的发展。
资源匮乏地区诊断途径有限
许多地区缺乏训练有素的神经科、影像基础设施和分子检测能力。农村和医疗服务不足的人面临诊断延迟和专科诊疗机会有限的问题。 PET扫描、脑脊髓液检测和基因检测的费用和可近性仍然是新兴市场的障碍。转诊途径分散和公众认知度低进一步损害了医疗品质。这些限制因素持续阻碍全球神经退化领域的公平性和治疗效果。
疫情扰乱了全球神经退化患者的临床试验、诊断和长期照护。封锁和资源重新分配减缓了患者获得治疗和疾病监测的速度。然而,疫情后的復苏策略强调神经科照护的韧性和数位转型。远端医疗、远距认知评估和数位生物标记已在老年族群中广泛应用。疫情期间,民众对神经系统健康的关注度有所提高,这影响了政策和研究重点。这些转变正在加速对基础设施、技术创新和以患者为中心的护理模式的投资。
预计在预测期内,阿兹海默症细分市场将成为最大的细分市场。
由于阿兹海默症领域将占据最大的市场份额。製药公司已推出针对淀粉样蛋白和Tau蛋白病理的单株抗体和疾病修正治疗。随着人口老化,对早期检测和风险分层的投资正在增加。与数位认知工具和体液生物标记的整合正在改善筛检和监测。各国政府正在资助失智症研究和护理协调计画。
预计细胞和基因治疗领域在预测期内将达到最高的复合年增长率。
随着治疗方法在罕见和进行性神经退化性疾病中的应用日益广泛,细胞和基因治疗领域预计将在预测期内呈现最高的成长率。研发人员正利用病毒载体、干细胞和基因编辑平台来恢復神经元功能并阻止疾病进展。监管机构正在为突破性疗法提供快速审查和有条件核准。对生产规模化和递送平台的投资正在提高治疗的准备度和可负担性。生物技术公司、医院和支付方之间的伙伴关係正在支持治疗的可及性和报销模式。
在预测期内,北美预计将占据最大的市场份额,这主要得益于其先进的研究基础设施、积极的监管参与以及人口老化趋势。美国和加拿大拥有众多领先的神经病学中心、临床试验网络和患者权益组织。美国食品药物管理局(FDA)的快速通道和突破性疗法认定等项目为创新和市场准入提供了支持。对生物标记开发和精准神经病学的投资正在推动平台扩张。领先的生物技术公司和学术机构的存在进一步巩固了其市场领导地位。
预计亚太地区在预测期内将呈现最高的复合年增长率,这主要得益于医疗现代化、人口老化和政策改革的共同推动。中国、日本、印度和韩国等国家正在扩大都市区地区神经系统疾病诊断和治疗的覆盖范围。政府支持的计画正在推动失智症筛检、公众意识提升和基础设施建设。区域生物技术公司正在推出针对特定族群适应症的细胞和基因疗法。公共和私人医疗系统对经济实惠且扩充性的解决方案的需求日益增长。这些趋势正在推动整个神经退化性疾病生态系统的区域性成长。
According to Stratistics MRC, the Global Neurodegenerative Disease Market is accounted for $64.4 billion in 2025 and is expected to reach $118.9 billion by 2032 growing at a CAGR of 9.15% during the forecast period. Neurodegenerative disease refers to a group of disorders characterized by the progressive loss of structure or function of neurons, leading to their gradual death. These conditions affect the brain and nervous system, impairing cognitive, motor, and sensory functions. Common examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). The underlying causes often involve abnormal protein accumulation, genetic mutations, oxidative stress, and mitochondrial dysfunction. As neurons cannot regenerate efficiently, these diseases are typically chronic and worsen over time. Neurodegenerative diseases pose significant medical and social challenges due to their complexity and lack of curative treatments.
Advances in biomarker & diagnostic technology
Researchers are developing fluid-based and imaging biomarkers to identify early-stage pathology in Alzheimer's, Parkinson's, and ALS. Integration with AI and machine learning is improving diagnostic accuracy and disease stratification. Pharmaceutical companies are using biomarkers to optimize trial design and therapeutic targeting. Companion diagnostics are gaining traction across precision neurology pipelines. These capabilities are propelling innovation in early intervention and personalized care.
Complex disease biology & heterogeneity
Many conditions involve multifactorial pathogenesis, including genetic, environmental, and inflammatory components. Disease progression varies widely across individuals, complicating trial endpoints and treatment response. Lack of validated animal models and translational biomarkers slows preclinical research. Regulatory bodies require robust evidence for efficacy and safety in heterogeneous populations. These challenges continue to hinder drug development and platform scalability.
Rising healthcare spending & awareness
Governments are funding national dementia strategies and aging-related research programs. Public campaigns are improving awareness and reducing stigma around cognitive decline and neurological disorders. Hospitals are expanding memory clinics and neurorehabilitation centers to meet rising demand. Investment in digital health and remote monitoring is supporting long-term care and disease management. These trends are fostering growth across prevention, diagnosis, and therapeutic innovation.
Limited diagnostic access in low-resource settings
Many regions lack trained neurologists, imaging infrastructure, and molecular testing capabilities. Rural and underserved populations face delays in diagnosis and limited access to specialized care. Cost and availability of PET scans, CSF assays, and genetic testing remain barriers in emerging markets. Fragmented referral pathways and low public awareness further degrade care quality. These constraints continue to hamper equity and outcomes across global neurodegenerative ecosystems.
The pandemic disrupted clinical trials, diagnostics, and long-term care for neurodegenerative patients worldwide. Lockdowns and resource reallocation delayed therapy access and disease monitoring. However, post-pandemic recovery strategies have emphasized resilience and digital transformation in neurology care. Telemedicine, remote cognitive assessments, and digital biomarkers gained traction across aging populations. Public awareness of neurological health increased during the crisis, influencing policy and research priorities. These shifts are accelerating investment in infrastructure, innovation, and patient-centric care models.
The alzheimer's disease segment is expected to be the largest during the forecast period
The alzheimer's disease segment is expected to account for the largest market share during the forecast period due to its high prevalence, diagnostic complexity, and therapeutic innovation. Pharmaceutical firms are launching monoclonal antibodies and disease-modifying therapies targeting amyloid and tau pathology. Investment in early detection and risk stratification is rising across aging populations. Integration with digital cognitive tools and fluid biomarkers is improving screening and monitoring. Governments are funding dementia research and care coordination programs.
The cell & gene therapies segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the cell & gene therapies segment is predicted to witness the highest growth rate as curative approaches gain traction across rare and progressive neurodegenerative conditions. Developers are using viral vectors, stem cells, and gene editing platforms to restore neuronal function and halt disease progression. Regulatory bodies are offering expedited review and conditional approvals for breakthrough therapies. Investment in manufacturing scale-up and delivery platforms is improving readiness and affordability. Partnerships between biotech firms, hospitals, and payers are supporting access and reimbursement models.
During the forecast period, the North America region is expected to hold the largest market share due to its advanced research infrastructure, regulatory engagement, and aging demographics. The United States and Canada host major neurology centers, clinical trial networks, and patient advocacy organizations. FDA programs such as Fast Track and Breakthrough Therapy Designation are supporting innovation and market entry. Investment in biomarker development and precision neurology is driving platform expansion. Presence of leading biotech firms and academic institutions is reinforcing leadership.
Over the forecast period, the Asia Pacific region is anticipated to exhibit the highest CAGR as healthcare modernization, aging populations, and policy reform converge. Countries like China, Japan, India, and South Korea are scaling neurology diagnostics and therapy access across urban and rural regions. Government-backed programs are supporting dementia screening, public awareness, and infrastructure development. Regional biotech firms are launching cell and gene therapies tailored to population-specific indications. Demand for affordable and scalable solutions is rising across public and private healthcare systems. These trends are accelerating regional growth across neurodegenerative disease ecosystems.
Key players in the market
Some of the key players in Neurodegenerative Disease Market include AbbVie Inc., Amneal Pharmaceuticals LLC, Boehringer Ingelheim GmbH, F. Hoffmann-La Roche Ltd., Merck & Co., Inc., Novartis AG, Pfizer Inc., Teva Pharmaceutical Industries Ltd., UCB S.A., Biogen Inc., Eli Lilly and Company, Johnson & Johnson, Eisai Co., Ltd., Lundbeck A/S and Denali Therapeutics Inc.
In January 2025, AbbVie exercised its first opt-in under the collaboration with Capsida Biotherapeutics, securing rights to a gene therapy program for neurodegenerative diseases. The decision followed promising primate data showing effective delivery of AbbVie's therapeutic payload to the brain using Capsida's engineered AAV capsids, while minimizing off-target effects in the liver and dorsal root ganglia.
In September 2023, Amneal launched IPX203 in the U.S. following FDA approval for Parkinson's disease. The extended-release formulation demonstrated superior "on-time" versus immediate-release carbidopa-levodopa in Phase 3 trials, offering improved symptom control and dosing convenience for patients with advanced Parkinson's.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.