市场调查报告书
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1562251
北美转染试剂和设备市场预测至 2030 年 - 区域分析 - 按产品、方法、应用和最终用户North America Transfection Reagents and Equipment Market Forecast to 2030 - Regional Analysis - by Product, Method, Application, and End User |
2022年北美转染试剂和设备市场价值为5.4057亿美元,预计2030年将达到9.9553亿美元;预计 2022 年至 2030 年复合年增长率为 7.9%。
公司的策略性措施推动北美转染试剂和设备市场
在北美转染试剂和设备市场运营的公司专注于策略发展,例如合作、扩张、协议、伙伴关係和新产品发布,这有助于他们提高销售、扩大地理范围并增强满足市场需求的能力。现有的客户群更大。这些发展也在一定程度上有助于向市场引入新趋势。以下提到了北美转染试剂和设备市场的一些值得注意的发展。
2023 年4 月,赛默飞世尔科技推出了Invitrogen Neon NxT 电穿孔系统,即使是最具挑战性的细胞类型,该系统也能促进转染,从而实现高效率、细胞回收率和重现性。 Neon NxT 电极经过最佳放置,可提供最小的表面积并产生更均匀的电场,并在转染过程中保持适当的生理条件,从而使所需的修饰能够在更多细胞中发生,并减少在此过程中损失的细胞数量。新系统还具有改进的回馈迴路和人体工学增强功能,易于使用。 2021年8月,Mirus Bio推出了TransIT VirusGEN GMP产品线,该产品线提供转染试剂和增强剂,以支持用于基因疗法开发的病毒载体的製造。 TransIT VirusGEN GMP 转染试剂旨在增强转移疫苗 DNA 向悬浮细胞和贴壁 HEK 293 细胞的递送,从而使重组 AAV 和 LV 载体的生产更加高效。 2020 年7 月,Polyplus-transfection SA 为其PEIpro 转染试剂产品组合推出了首个符合GMP 规定的残留测试,旨在支持慢病毒和腺相关病毒(AAV) 生产的临床前、临床和商业流程的开发细胞和基因疗法。此外,Polyplus-transfection 还推出了用于后期和商业化细胞和基因疗法的 PEIpro-GMP 产品的双重采购。因此,推出了转染试剂和系统等产品;开发针对各种健康问题的创新产品,以创造新的或改进的产品;以及启动新业务以保持市场竞争力,所有这些透过合作和伙伴关係都可以帮助加快转染试剂和设备新平台的开发。
北美转染试剂与设备市场概况
细胞和基因疗法(CGT)用于治疗严重和罕见疾病且治疗需求未满足的患者。製造 CGT 是一个高度复杂的过程,基础设施和专业知识的不足是一个主要限制。与中间体和最终产品相关的物流相关挑战也限制了公司的 CGT 製造能力。 CGT的製造过程包括透过「单采术」提取自体细胞,将其送往专门实验室,然后送回诊所给患者施用,所有这些都必须在严格的品质控制下进行。迄今为止,美国食品药物管理局 (FDA) 仅批准了 7 种 CGT 药物,新产品管线已达到约 1,200 种实验疗法。其中一半正在进行二期临床试验。根据《2023 年化学与工程新闻报告》,鑑于这些前景,细胞疗法和基因疗法的年销售额预计将分别成长 15% 和 30% 左右。
许多製造商与 Labcorp、Lonza 和 Catalent 等合约开发製造组织 (CDMO) 接洽,以克服与其 CGT 产品生产和商业化相关的障碍。 Lonza 已投资约 920 万美元来增强其细胞和基因治疗製造能力。 CDMO 的此类措施正在促进美国转染试剂和设备市场的成长。
此外,2022年2月,创新、科学与工业部长Francois-Philippe Champagne宣布透过加拿大创新基金会(CFI)向加拿大政府提供4,500万美元资金,以确保研究团队拥有合适的实验室和基础设施,以及利用技术部门进行世界一流研究的机会。加拿大卫生研究院 (CIHR) 宣布与魁北克药物发现联盟 (CQDM) 建立合作伙伴关係,以开展一项新的个人化医疗合作资助计划,以加速药物发现和药物开发。
北美转染试剂和设备市场收入及2030年预测(百万美元)
北美转染试剂与设备市场细分
北美转染试剂和设备市场根据产品、方法、应用、最终用户和国家进行细分。
根据产品,北美转染试剂和设备市场分为试剂和仪器。 2022 年,试剂细分市场将占更大份额。
从方法来看,北美转染试剂和设备市场分为病毒方法、非病毒方法和混合方法。 2022 年,非病毒方法部分占最大份额。非病毒部分分为物理/机械方法和化学方法。此外,物理/机械方法细分为电穿孔、显微注射、生物弹体方法、雷射方法、磁转染和声穿孔。此外,化学方法部分又分为基于脂质体/高脂质和基于非脂质体/高脂质。
按应用划分,北美转染试剂和设备市场分为生物医学研究、蛋白质生产和治疗递送。 2022 年,生物医学研究领域占最大份额。
根据最终用户,北美转染试剂和设备市场分为学术和研究机构以及製药和生物技术公司。 2022 年,学术和研究机构领域占据了更大的份额。
依国家划分,北美转染试剂和设备市场分为美国、加拿大和墨西哥。 2022年,美国主导北美转染试剂和设备市场。
Thermo Fisher Scientific Inc、Promega Corp、F. Hoffmann-La Roche Ltd、Bio-Rad Laboratories Inc、Mirus Bio LLC、QIAGEN NV、Merck KGaA、Lonza Group AG、MaxCyte Inc 和 Polyplus-Transfection SA 是一些领先公司经营北美转染试剂和设备市场。
The North America transfection reagents and equipment market was valued at US$ 540.57 million in 2022 and is expected to reach US$ 995.53 million by 2030; it is estimated to register at a CAGR of 7.9% from 2022 to 2030.
Strategic Initiatives by Companies Fuel North America Transfection Reagents and Equipment Market
Companies operating in the North America transfection reagents and equipment market focus on strategic developments such as collaborations, expansions, agreements, partnerships, and new product launches, which help them improve their sales, expand their geographic scope, and enhance their capacities to cater to a larger than existing customer base. These developments also contribute to the introduction of new trends to the market to a certain extent. A few of the noteworthy developments in the North America transfection reagents and equipment market are mentioned below.
In April 2023, Thermo Fisher Scientific launched the Invitrogen Neon NxT Electroporation System that facilitates transfection, even with the most challenging cell types, enabling high efficiency, cell recovery, and reproducibility. Neon NxT electrodes are optimally placed to provide minimal surface area and create a more uniform electric field, and maintain apt physiological conditions during transfection, thereby enabling the desired modification to take place in more cells and reducing the number of cells lost during the process. The new system also features an improved feedback loop and ergonomic enhancements for ease of use. In August 2021, Mirus Bio launched the TransIT VirusGEN GMP Product Line, which provides transfection reagents and enhancers to support the manufacturing of viral vectors for the development of gene therapies. The TransIT VirusGEN GMP transfection reagent was developed to enhance the delivery of transfer vaccine DNA to suspension and adherent HEK 293 cells to make the production of recombinant AAV and LV vectors more efficient. In July 2020, Polyplus-transfection SA launched the first GMP-compliant residual test for its PEIpro product portfolio of transfection reagents designed to support the development of the preclinical, clinical, and commercial process of lentivirus and adeno-associated virus (AAV) production for cell and gene therapies. In addition, Polyplus-transfection also launched dual sourcing for its PEIpro-GMP product for late-stage and commercialization cell and gene therapies. Thus, the introduction of products such as transfection reagents and systems; the development of innovative products targeting various health issues to create new or improved products; and the initiation of new businesses to remain competitive in the market, all, through collaborations and partnerships can help speed up the development of new platforms for transfection reagents and equipment.
North America Transfection Reagents and Equipment Market Overview
Cell and gene therapies (CGTs) are prescribed to treat patients suffering from serious and rare diseases with unaddressed therapeutic needs. Manufacturing CGTs is a highly complex process, with the insufficiency of infrastructure and expertise being a major limiting factor. Logistics-related challenges associated with intermediates and the final product also limit the CGT manufacturing capacity of companies. The CGT manufacturing process involves the extraction of autologous cells through "apheresis," dispatching them to specialized laboratories and sending them back to clinics for administration into patients, all of which must be performed with strict quality control. The US Food and Drug Administration (FDA) has approved only 7 CGT drugs so far, and the pipeline of new products has reached ~1,200 experimental therapies. Half of these are in Phase 2 clinical trials. With these prospects, annual sales of cell therapies and gene therapies are estimated to grow by 15% and ~30%, respectively, as stated in the Chemical & Engineering News Report 2023.
Many manufacturers approach contract development manufacturing organizations (CDMOs) such as Labcorp, Lonza, and Catalent to overcome the barriers associated with the production and commercialization of their CGT products. Lonza has invested ~US$ 9.2 million to strengthen its cell and gene therapy manufacturing capabilities. Such initiatives by CDMOs are contributing to the growth of the transfection reagents and equipment market in the US.
Furthermore, in February 2022, Francois-Philippe Champagne, the minister of Innovation, Science and Industry, announced the funding of US$ 45 million to the Government of Canada through the Canada Foundation for Innovation (CFI) to ensure that research teams have appropriate labs and infrastructure, and access to technology departments for carrying about world-class research. The Canadian Institutes of Health Research (CIHR) announced a partnership with the Quebec Consortium for Drug Discovery (CQDM) for a new collaborative funding program on personalized medicine to accelerate drug discovery and drug development.
North America Transfection Reagents and Equipment Market Revenue and Forecast to 2030 (US$ Million)
North America Transfection Reagents and Equipment Market Segmentation
The North America transfection reagents and equipment market is segmented based on product, method, application, end user, and country.
Based on product, the North America transfection reagents and equipment market is bifurcated into reagents and instruments. The reagents segment held a larger share in 2022.
In terms of method, the North America transfection reagents and equipment market is segmented into viral methods, non-viral methods, and hybrid methods. The non-viral methods segment held the largest share in 2022. The viral segment is sub categorized into retrovirus, adenovirus, adeno associated virus, and herpes virus. The non-viral segment is bifurcated into physical/mechanical method and chemical method. Further, the physical/mechanical method segment is sub categorized into electroporation, microinjection, biolistic method, laser method, magnetofection, and sonoporation. Also, the chemical method segment is sub categorized into liposomal based/high lipid and non-liposomal/high lipid based.
By application, the North America transfection reagents and equipment market is segmented into biomedical research, protein production, and therapeutic delivery. The biomedical research segment held the largest share in 2022.
Based on end user, the North America transfection reagents and equipment market is bifurcated into academics & research institutes and pharmaceutical & biotechnology companies. The academics & research institutes segment held a larger share in 2022.
Based on country, the North America transfection reagents and equipment market is categorized into the US, Canada, and Mexico. The US dominated the North America transfection reagents and equipment market in 2022.
Thermo Fisher Scientific Inc, Promega Corp, F. Hoffmann-La Roche Ltd, Bio-Rad Laboratories Inc, Mirus Bio LLC, QIAGEN NV, Merck KGaA, Lonza Group AG, MaxCyte Inc, and Polyplus-Transfection SA are some of the leading companies operating in the North America transfection reagents and equipment market.