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市场调查报告书
商品编码
1871423
2021-2031年北美微电极阵列体外市场报告:范围、细分、动态和竞争分析North America Microelectrode Array In Vitro Market Report 2021-2031 by Scope, Segmentation, Dynamics, and Competitive Analysis |
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2023 年北美微电极阵列体外市场价值约为 844 万美元,预计到 2031 年将成长至 1,194 万美元,在此期间的年复合成长率(CAGR) 为 4.4%。
神经科学研究需求不断成长
神经科学研究领域对微电极阵列(MEA)日益增长的需求是北美市场的重要驱动力。这些阵列对于在神经元培养物上测试新药至关重要,使研究人员能够评估药物对神经活动的影响并开发标靶疗法。体外模型被用于研究一系列神经系统和神经精神疾病,包括阿兹海默症、帕金森氏症、癫痫和各种神经发育障碍。这些疾病的日益普遍导致了对微电极阵列系统需求的增加,该系统有助于研究与这些疾病相关的细胞和分子变化及其对神经功能的影响。
透过在体外细胞模型中使用微电极阵列,研究人员可以测量神经活动,并评估药物化合物如何调节这种活动、恢復正常的神经网路功能或对抗疾病相关的异常。这项能力对于在研发早期阶段识别有前景的候选药物至关重要。随着神经科学研究的不断发展,Axion BioSystems、Multi Channel Systems 和 MaxWell Biosystems 等公司正在不断创新并推出新产品以满足这一需求。例如,Axion BioSystems 于 2024 年 4 月推出了 Maestro Volt,这是一款经济高效的桌上型微电极阵列系统,专为通量要求较低的学术实验室而设计。这款 6 孔设备适用于神经系统和心血管系统研究,具有用户友好的控制功能和 Maestro 品牌一贯的高品质标准。
北美市场概览
投资者对生产用于体外研究的高通量微电极阵列的公司越来越感兴趣,这些微电极阵列对研究机构、製药公司和生物技术行业至关重要。基于CMOS的微电极阵列、干细胞研究、神经假体和体外毒理学测试等领域的创新正在推动对这些技术的需求。值得注意的是,2020年6月,乔治亚州立大学研究基金会从美国国家科学基金会获得了1.9756亿美元的资助,用于开髮用于SARS-CoV-2和其他RNA病毒的微电极阵列感测器,这展现了这些技术在应对全球健康挑战方面的巨大潜力。
美国环保署也认可微电极阵列是进行体外毒性测试的宝贵工具,尤其是在评估发育神经毒性方面,而发育神经毒性是新化学物质和药物审批过程中面临的重大挑战。这种监管支持促使微电极阵列在药物发现和疾病建模中的高通量筛选方面得到更广泛的应用,因为研究人员正在寻求可靠的平台来即时监测细胞和组织活动。
微电极阵列在类器官等创新体外模型中的应用,推动了包括3D微电极阵列技术和高密度CMOS微电极阵列在内的先进技术的发展。例如,2023年1月,美国微电极阵列技术供应商BMSEED为其二维可拉伸微电极阵列(sMEA)申请了专利,该阵列已升级为三维版本,可用于对脑类器官和3D组织培养物进行电生理测量,尤其是在阿兹海默症研究中。这种3D-sMEA技术具有可调节的、嵌入电极的微腔,能够贴合类器官的形状,使研究人员能够从完整类器官约80%的表面积上采集神经讯号。
市场区隔
北美体外微电极阵列市场按产品、应用和国家进行细分。按产品划分,市场分为传统微电极阵列 (MEA)、多孔微电极阵列 (multiwell-MEA) 和 CMOS 微电极阵列 (CMOS-MEA),其中多孔微电极阵列在 2023 年占据最大的市场份额。按应用划分,市场分为心肌细胞、神经和其他,其中心肌细胞应用领域也占据领先的市场份额。按国家/地区划分,市场分为美国、加拿大和墨西哥,其中美国在 2023 年占据市场主导地位。
关键参与者
北美微电极阵列体外市场的主要公司包括:Tucker Davis Technologies、SCREEN Holdings Co., Ltd.、Plexon Inc.、MaxWell Biosystems AG、Harvard Bioscience Inc.、Axion BioSystems Inc.、3Brain AG、NeuroNexus Technologies Inc.、MiElectrodepvic、TirkEED这些公司致力于开发创新解决方案,以满足神经科学及相关领域日益增长的需求。
The North America microelectrode array in vitro market was valued at approximately US$ 8.44 million in 2023 and is projected to grow to US$ 11.94 million by 2031, reflecting a compound annual growth rate (CAGR) of 4.4% during this period.
Increasing Demand in Neuroscience Research
The rising demand for microelectrode arrays (MEAs) in neuroscience research is a significant driver of the North American market. These arrays are essential for testing new pharmaceuticals on neuronal cultures, allowing researchers to evaluate the impact of drugs on neural activity and develop targeted therapies. In vitro models are utilized to study a range of neurological and neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and various neurodevelopmental conditions. The growing prevalence of these disorders has led to an increased need for microelectrode array systems, which facilitate the examination of cellular and molecular changes associated with these diseases and their effects on neural functions.
By employing microelectrode arrays in in vitro cell models, researchers can measure neural activity and assess how drug compounds can modulate this activity, restore normal network function, or counteract disease-related abnormalities. This capability is crucial for identifying promising drug candidates early in the development process. As neuroscience research continues to expand, companies like Axion BioSystems, Multi Channel Systems, and MaxWell Biosystems are innovating and launching new products to meet this demand. For example, in April 2024, Axion BioSystems introduced the Maestro Volt, a cost-effective benchtop microelectrode array system designed for academic laboratories with lower throughput requirements. This 6-well device is suitable for both neurological and cardiovascular research, featuring user-friendly controls and high-quality standards associated with the Maestro brand.
North America Market Overview
Investors are increasingly interested in companies that manufacture high-throughput microelectrode arrays for in vitro research, which are essential for research institutions, pharmaceutical companies, and the biotechnology sector. Innovations in CMOS-based microelectrode arrays, stem cell research, neuroprosthetics, and in vitro toxicology testing are propelling the demand for these technologies. Notably, in June 2020, the Georgia State University Research Foundation received US$ 197.56 million from the US National Science Foundation to develop microelectrode array sensors for SARS-CoV-2 and other RNA viruses, showcasing the potential of these technologies to address global health challenges.
The US Environmental Protection Agency has also recognized microelectrode arrays as valuable tools for conducting in vitro toxicity tests, particularly for assessing developmental neurotoxicity, which poses significant challenges in the approval of new chemicals and drugs. Such regulatory support has led to increased use of microelectrode arrays for high-throughput screening in drug discovery and disease modeling, as researchers seek reliable platforms for real-time monitoring of cellular and tissue activity.
The adoption of microelectrode arrays in innovative in vitro models, such as organoids, has spurred the development of advanced technologies, including 3D microelectrode array technology and high-density CMOS-based microelectrode arrays. For instance, in January 2023, BMSEED, a US-based provider of microelectrode array technologies, filed a patent application for its 2D stretchable microelectrode array (sMEA) that has been enhanced into a 3D version, allowing for electrophysiological measurements from brain organoids and 3D tissue cultures, particularly in Alzheimer's research. This 3D-sMEA technology features adjustable pockets with embedded electrodes that conform to organoids, enabling researchers to capture neural signals from approximately 80% of the surface area of intact organoids.
Market Segmentation
The North America microelectrode array in vitro market is segmented by product, application, and country. In terms of product, the market is divided into classical MEA, multiwell-MEA, and CMOS-MEA, with the multiwell-MEA segment holding the largest market share in 2023. Regarding application, the market is categorized into cardiomyocytes, nerve, and others, with the cardiomyocytes segment also leading in market share. By country, the market is segmented into the US, Canada, and Mexico, with the US dominating the market in 2023.
Key Players
Leading companies in the North America microelectrode array in vitro market include Tucker Davis Technologies, SCREEN Holdings Co., Ltd., Plexon Inc., MaxWell Biosystems AG, Harvard Bioscience Inc., Axion BioSystems Inc., 3Brain AG, NeuroNexus Technologies Inc., MicroElectrodeDevices, Blackrock Microsystems, Inc., NMI Technologietransfer GmbH, and BMSEED. These companies are at the forefront of developing innovative solutions to meet the growing demands of neuroscience and related fields.