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小鼠模型市场:按类型、技术、治疗领域、应用分类 - 2024-2030 年全球预测Mice Model Market by Type (Conditioned/Surgically Modified Mice, Genetically Engineered Mice, Hybrid/Congenic Mice), Technology (CRISPR/CAS9, Embryonic Stem Cell Injection, Microinjection), Therapeutic Area, Application - Global Forecast 2024-2030 |
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预计2023年滑鼠模型市场规模为14.9亿美元,2024年达到16.1亿美元,预计2030年将达到26.1亿美元,复合年增长率为8.34%。
小鼠模型是科学家和研究人员用于生物医学研究以及与基因工程、药物发现和治疗测试相关的研究的实验室小鼠(小家鼠)。由于人类和小鼠在遗传、生物学和行为上相似,因此这些模型对于模拟人类疾病过程至关重要。小鼠模型使科学界能够了解疾病机制,评估药物的有效性,并在人体测试之前探索潜在的治疗方法。对个人化医疗的需求不断增长,各种遗传疾病的盛行率不断增加,以及包括癌症、心血管和神经系统疾病在内的生物医学研究的激增,正在推动小鼠模型的使用增加。此外,越来越多的药物监管核准需要广泛的临床前测试,进一步推动了对小鼠模型的需求。儘管显着增长,小鼠模型市场仍然受到与动物实验相关的伦理问题、创建和维护基因工程小鼠模型的高成本以及在小鼠中复製人类疾病的复杂性的限制,面临一些挑战。然而,CRISPR/Cas9基因编辑技术的持续发展为创建更准确和多样化的疾病模型提供了新途径。此外,全球公共和私营部门对生物医学研究和开发的投资增加也极大地推动了市场的发展。
主要市场统计 | |
---|---|
基准年[2023] | 14.9亿美元 |
预测年份 [2024] | 16.1亿美元 |
预测年份 [2030] | 26.1亿美元 |
复合年增长率(%) | 8.34% |
基因转殖小鼠对于评估类型基因治疗的结果越来越重要
经过调理或手术改造的小鼠透过手术干预进行专门改造,以创建代表小鼠基因组中不自然存在的人类状况的模型。这些修改包括移除特定器官、引入肿瘤或创建损伤模型。这种方法使研究人员能够在严格模仿他们想要重现的人类生理条件的受控环境中研究疾病机制、开发外科技术并评估治疗药物。基因工程小鼠(GEM)是透过操纵遗传物质而产生的。基因敲除、基因敲入和基因转殖等技术用于引入、移除或修饰小鼠基因组内的特定基因。这类小鼠模型对于研究基因功能、疾病的遗传基础、基因改造的潜在影响非常重要。混合/同类小鼠是透过受管制育种策略产生的,将来自两个或多个品系的遗传物质组合起来以获得特定的遗传背景。混合小鼠透过杂交两种不同的近交系,提供杂合性和广泛的遗传多样性,有助于整体健康和繁殖性能。另一方面,同源小鼠是透过将混合小鼠与原始近交系之一回交多代而产生的,从而可以分离特定的遗传性状或基因座。近亲交配小鼠是兄弟姊妹或亲代与后代之间至少 20 代交配的结果,产生了遗传同质的品系。这些小鼠具有一致的遗传背景,这最大限度地减少了实验研究中的变异性,使它们在研究中具有无价的价值。近交系小鼠广泛用于遗传学、免疫学和疾病模型研究,也被用作开发基因工程模型和药理毒理学研究的平台。近交小鼠是一个基因多样化的群体,有意保持杂合性。这种遗传多样性反映了人类群体内的遗传多样性,对于毒理学、药理学和安全性评估研究特别有用。
越来越多地采用应用小鼠模型,可以在临床试验之前研究治疗效果和安全性
小鼠模型在药物发现和药物开发中的应用对于製药业至关重要。人类和小鼠在生理和遗传上相似,这使得它们对于评估新药物化合物的功效和安全性具有无价的价值。透过利用小鼠模型,研究人员可以阐明潜在治疗药物的药物动力学和动态特性,并确定有前途的候选药物以进行进一步开发。此外,这些模型可以帮助在进入人体临床试验之前了解新药的作用机制、剂量反应关係和潜在毒性,从而最大限度地降低后期开发阶段失败的风险。小鼠模型对于个人化医疗的进步至关重要。基因工程小鼠和患者来源的异质骨移植(PDX)使研究人员能够高精度地模拟人类遗传状况和疾病。这使得根据基因组成研究个体对治疗药物的反应成为可能,从而製定更精确、更有效的治疗策略。个人化小鼠模型有助于识别疾病诊断的生物标记、预测治疗结果和评估标靶治疗。除了在药物开发和个人化医疗中发挥重要作用外,小鼠模型还广泛用于各种生物医学研究应用。其中包括研究遗传学、阐明疾病机制、测试免疫反应以及评估环境因素对健康的影响。小鼠模型在增进我们对癌症、心血管疾病、糖尿病和神经系统疾病等复杂疾病的认识方面发挥着至关重要的作用。其多功能性和适应性也使其适用于再生医学研究和老化研究,为生物医学知识的扩展和新治疗方法的寻找做出了重大贡献。
区域洞察
由于研究机构和製药公司的持续研究活动,美洲的关键字市场正在显着成长。此外,联邦对药物和疫苗开发的津贴和投资正在扩大该地区的小鼠模型市场。然而,欧洲国家遗传性疾病和神经系统併发症的增加增加了小鼠模型的使用来了解与老龄化相关的疾病。此外,新兴的临床研究机构和有利的政府措施正在支持欧洲、中东和非洲地区的市场开拓。对个人化治疗的需求不断增长、老年疾病的扩散、免疫疾病病例的增加以及感染疾病患者病率的增加,正在推动美洲和欧洲地区采用小鼠模型。另一方面,由于研究活动和政府临床活动倡议的增加,预计亚太地区的小鼠模型市场在预测期内将显着成长。亚太地区的人口成长和慢性病的流行凸显了广泛研究的必要性,并鼓励采用小鼠模型。
FPNV定位矩阵
FPNV定位矩阵对于评估老鼠模型市场至关重要。我们检视与业务策略和产品满意度相关的关键指标,以对供应商进行全面评估。这种深入的分析使用户能够根据自己的要求做出明智的决策。根据评估,供应商被分为四个成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市场占有率分析
市场占有率分析是一种综合工具,可以对滑鼠模型市场供应商的现状进行深入而详细的研究。全面比较和分析供应商在整体收益、基本客群和其他关键指标方面的贡献,以便更好地了解公司的绩效及其在争夺市场占有率时面临的挑战。此外,该分析还提供了对该行业竞争特征的宝贵见解,包括在研究基准年观察到的累积、分散主导地位和合併特征等因素。详细程度的提高使供应商能够做出更明智的决策并制定有效的策略,以获得市场竞争优势。
1. 市场渗透率:提供有关主要企业所服务的市场的全面资讯。
2. 市场开拓:我们深入研究利润丰厚的新兴市场,并分析其在成熟细分市场的渗透率。
3. 市场多元化:提供有关新产品发布、开拓地区、最新发展和投资的详细资讯。
4.竞争评估与资讯:对主要企业的市场占有率、策略、产品、认证、监管状况、专利状况、製造能力等进行全面评估。
5. 产品开发与创新:提供对未来技术、研发活动和突破性产品开发的见解。
1. 滑鼠模型市场的市场规模与预测是多少?
2.在滑鼠模型市场预测期内,有哪些产品、细分市场、应用和领域需要考虑投资?
3. 滑鼠模型市场的技术趋势和法规结构是什么?
4.滑鼠模型市场主要厂商的市场占有率是多少?
5.进入滑鼠模型市场合适的型态和策略手段是什么?
[187 Pages Report] The Mice Model Market size was estimated at USD 1.49 billion in 2023 and expected to reach USD 1.61 billion in 2024, at a CAGR 8.34% to reach USD 2.61 billion by 2030.
Mice models are laboratory mice (Mus musculus) used by scientists and researchers for biomedical research and studies related to genetic engineering, drug discovery, and therapeutic testing. These models are pivotal in mimicking human disease processes due to the genetic, biological, and behavioral similarities between humans and mice. Mice models enable the scientific community to understand disease mechanisms, assess drug efficacy, and explore potential treatments before they are tested in humans. The increasing demand for personalized medicine, the growing prevalence of various genetic disorders, and a surge in biomedical research involving cancer, cardiovascular diseases, and neurological disorders enhanced the usage of mice models. The rise in regulatory approvals for pharmaceutical drugs also necessitates extensive preclinical studies, further propelling the demand for mice models. Despite the significant growth, the mice model market faces several challenges, such as ethical concerns related to animal testing, the high cost of creating and maintaining genetically engineered mice models, and the complexity of reproducing human diseases in mice. However, the continual development of CRISPR/Cas9 gene-editing technology presents novel avenues for creating more accurate and diverse disease models. Additionally, the increasing investment in biomedical research and development by both public and private sectors worldwide offers a significant boost to the market.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 1.49 billion |
Estimated Year [2024] | USD 1.61 billion |
Forecast Year [2030] | USD 2.61 billion |
CAGR (%) | 8.34% |
Type: Growing significance of genetically engineered mice for evaluating gene therapy outcomes
Conditioned or surgically modified mice are specifically altered through surgical interventions to create models that represent human conditions not naturally occurring in the mouse genome. These modifications can include the removal of specific organs, the introduction of tumors, or the creation of injury models. This methodology allows for the study of disease mechanisms, the development of surgical techniques, and the evaluation of therapeutics in a controlled environment, closely mimicking the human physiological conditions they aim to replicate. Genetically engineered mice (GEM) are created by manipulating their genetic material. Techniques such as gene knockout, gene knock-in, and transgenesis are employed to introduce, remove, or alter specific genes within the mouse genome. This category of mice models is important for studying gene function, the genetic basis of diseases, and the potential effects of genetic modifications. Hybrid/congenic mice are produced through controlled breeding strategies to combine genetic material from two or more strains to achieve specific genetic backgrounds. Hybrid mice result from mating two different inbred strains, offering heterozygosity and broader genetic diversity, which is beneficial for general health and reproductive performance. Congenic mice, on the other hand, are created by backcrossing hybrids to one of the original inbred strains for multiple generations, allowing for the isolation of specific genetic traits or loci. Inbred mice are derived from at least 20 generations of brother-sister or parent-offspring mating, which results in a genetically uniform strain. These mice are invaluable in research owing to their consistent genetic background, which minimizes variability in experimental studies. Inbred strains are used extensively in the study of genetics, immunology, and disease models, including as platforms for developing genetically engineered models and for pharmacological and toxicological studies. Outbred mice are genetically diverse populations that are kept deliberately heterozygous. This genetic variability mirrors the genetic diversity within human populations, making them particularly useful for toxicology, pharmacology, and safety assessment studies.
Application: Rising adoption of mice models to explore therapeutic efficacy and safety profiles before clinical trials
The applications of mice models in drug discovery and development are essential for the pharmaceutical industry. The physiological and genetic similarities between humans and mice make them invaluable for assessing the efficacy and safety of new pharmaceutical compounds. By utilizing mice models, researchers can elucidate the pharmacokinetic and pharmacodynamic properties of potential therapeutic agents, enabling the identification of promising drug candidates for further development. Moreover, these models help in understanding the mechanism of action, dose-response relationship, and potential toxicity of new drugs before entering human clinical trials, thereby minimizing the risk of failure at later development stages. Mice models are pivotal in the advancement of personalized medicine. Using genetically engineered mice and patient-derived xenografts (PDX), researchers can mimic human genetic conditions and diseases at a high level of accuracy. This enables the study of individual responses to therapeutics based on genetic makeup, leading to more precise and effective treatment strategies. Personalized mice models are instrumental in identifying biomarkers for disease diagnosis, predicting therapeutic outcomes, and evaluating targeted therapies. Besides their significant role in drug development and personalized medicine, mice models are extensively used in various biomedical research applications. These include studying genetics, understanding disease mechanisms, testing immunological responses, and evaluating the impact of environmental factors on health. Mice models have been crucial in advancing our knowledge of complex diseases such as cancer, cardiovascular diseases, diabetes, and neurological disorders. Their versatility and adaptability also make them suitable for regenerative medicine studies and aging research, contributing profoundly to expanding biomedical knowledge and exploring new therapeutic avenues.
Regional Insights
The mice model market is growing significantly in the Americas owing to continuous research activities by research organizations and pharmaceutical companies. Moreover, federal government support in terms of grants and investment for drug development and vaccine development has enhanced the scope of the mice model in the region. However, the rising genetic disease and neurological complications in European countries have increased the utilization of mouse models to understand age-related diseases. In addition, emerging clinical research institutes and favorable government initiatives drive market development in the EMEA region. The rising need for personalized medications, surging geriatric disease, increasing cases of immune disease, and growing prevalence of infectious disease boost the adoption of mice models across the Americas and Europe regions. On the other hand, the Asia-Pacific region witnesses significant growth prospects of the mice models market in the forecast period owing to growing research activities and government initiatives for clinical activities. APAC's increasing population and prevalence of chronic diseases underscore the need for extensive research, thereby propelling the adoption of mice models.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Mice Model Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Mice Model Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Mice Model Market, highlighting leading vendors and their innovative profiles. These include Applied StemCell, Inc., Aragen Life Sciences Ltd., Biocytogen Boston Corporation, Charles River Laboratories International, Inc., CompareNetworks, Inc., Creative Biolabs., Crown Bioscience by JSR Life Sciences, LLC, Cyagen US Inc. by PolyGene AG, Envigo by Inotiv, Inc., GenOway, Harbour BioMed, Horizon Discovery Ltd. by PerkinElmer, Inc., inGenious Targeting Laboratory, Inc., ITR Laboratories Canada, Janvier Labs, Marshall BioResources, MD Biosciences, Mirimus, Inc., Oncodesign, SA, Ozgene Pty Ltd., PhoenixBio Co., Ltd., Shanghai Model Organisms Center, Inc., Taconic Biosciences, Inc., The Jackson Laboratory, TransCure bioServices, Translational Drug Development, LLC, Transnetyx, Inc., Urosphere SAS, Vivo Bio Tech Ltd., and XenOPAT SL by Bellvitge Biomedical Research Institute.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Mice Model Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Mice Model Market?
3. What are the technology trends and regulatory frameworks in the Mice Model Market?
4. What is the market share of the leading vendors in the Mice Model Market?
5. Which modes and strategic moves are suitable for entering the Mice Model Market?