市场调查报告书
商品编码
1574655
全球癌症抗体药物复合物市场:市场规模、药物批准、价格、销售和临床试验的见解(2030)Global Cancer Antibody Drug Conjugates Market Size, Drugs Approval, Price, Sales & Clinical Trials Insight 2030 |
抗体药物复合物(ADC)已成为癌症治疗中的创新治疗剂,它将单株抗体的特异性与细胞毒性药物的功效相结合。这种创新疗法由透过稳定连接体与细胞毒性药物结合的抗体组成,可针对癌细胞,同时最大限度地减少对周围健康组织的损害。抗体药物复合物的快速发展反映了它们在临床和商业上的成功,目前有16个产品在各个市场获得批准,销售额预计将在2023年达到100亿美元,并在2024年首次达到6个月内超过70亿美元。这种成长凸显了抗体药物复合物是更广泛的癌症药物市场中商业上可行的部分,并推动了研究和开发工作,以创造更有效和安全的候选化合物。
截至2024年 10月,全球监管机构已批准 16 种抗体药物复合物,其中 13 种目前可用于临床用于治疗各种癌症类型。其中,代表性的有Padceb、Kadcyla、Enherz等,2023年将占抗体药物复合物总销售额的60%左右。 Enhertu 适用于治疗多种 HER2 阳性实体肿瘤,而 Padcev 和 Kadcyla 仅分别被批准用于治疗膀胱癌和乳癌。这些产品类型显示市场对 ADC 的治疗潜力以及治疗各种癌症类型的有效性越来越有信心。
全球癌症抗体药物复合物市场的特点是竞争格局,针对包括实体肿瘤和血液恶性肿瘤在内的多种癌症的积极发展。然而,其中肺癌目前的开发活动最为广泛,有超过60个候选药物处于临床试验中,包括CAB-AXL-ADC、TQB2102和MYTX-011,其中一个Enhertu已经获得批准。这反映出肺癌治疗的策略转变,肺癌仍然是全球癌症死亡的主要原因之一,并且有很高的未满足的医疗需求。抗体-药物复合物有可能提供更有效、毒性更小的治疗选择,并且在该治疗领域特别有吸引力。
功能 | 详细资料 |
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关键片段 | 应用:癌症类型、区域、技术平台 |
涵盖的适应症 | 目标疾病:肺癌、乳癌、子宫颈癌、胰臟癌、食道癌等 |
主要目标国 | 美国、中国、韩国、加拿大、印度等 |
目标药 | Enhertu、Adcetris、Polivy、Kadcyla 等 |
报告范围 | 作用模式、ADC生成、管道和批准的药物见解、销售见解、当前趋势、未来机会、市场驱动因素和挑战 |
目标公司 | Biocytogen、Merck、AstraZeneca、Pfizer、Daiichi Sankyo、ADC Therapeutics等 |
本报告调查了全球癌症抗体药物复合物市场,并提供了市场概况以及药物趋势、临床试验趋势、区域趋势以及进入市场的公司的竞争格局。
"Global Cancer Antibody Drug Conjugates Market Size, Drugs Approval, Price, Sales & Clinical Trials Insight 2030" Report Finding and Inclusions:
Features | Details |
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Key Segments: | Application by Cancer Type, By Region, Technology Platforms |
Indications Covered: | Lung Cancer, Breast Cancer, Cervical Cancer, Pancreatic Cancer, Pancreatic Cancer, Esophageal Cancer, among others |
Key Countries Covered: | US, China, South Korea, Canada, India, among others |
Drugs Covered: | Enhertu, Adcetris, Polivy, Kadcyla, among others |
Report Coverage: | Mechanism of Action, ADC Generations, Pipeline & Approved Drugs Insight, Sales Insight, Current Trends, Future Opportunities, Market Drivers & Challenges |
Companies Covered: | Biocytogen, Merck, AstraZeneca, Pfizer, Daiichi Sankyo, ADC Therapeutics, among others |
Antibody drug conjugates (ADCs) have emerged as a transformative class of therapeutics in the cancer treatment landscape, integrating the specificity of monoclonal antibodies with the potency of cytotoxic drugs. These innovative therapies consist of an antibody linked to a cytotoxic agent through a stable linker, allowing targeted delivery to cancer cells while minimizing damage to surrounding healthy tissues. The rapid evolution of antibody drug conjugates reflects their clinical and commercial success, with 16 products currently approved across various markets and sales surpassing US$ 10 Billion in 2023 and US$ 7 Billion in the first 6 months of 2024. This growth highlights antibody drug conjugates as a commercially viable segment of the broader cancer therapeutics market, prompting increased research and development efforts to create more effective and safer candidates.
As of October 2024, regulatory authorities around the world have approved 16 antibody drug conjugates, with 13 currently available for clinical use for different cancer types. Among these, prominent examples include Padcev, Kadcyla, and Enhertu, which collectively accounted for approximately 60% of the total antibody drug conjugates sales in 2023. While Enhertu is indicated for the treatment of several HER2-positive solid cancers, Padcev and Kadcyla are solely approved for the treatment of bladder cancer and breast cancer, respectively. The commercialization of these products demonstrates not only their therapeutic potential but also the market's growing confidence in the effectiveness of ADCs in managing various cancer types.
Global cancer antibody drug conjugates market is characterized by a competitive landscape, with substantial development efforts targeting multiple cancers, including both solid tumors and hematological malignancies. However, out of all these, lung cancer is currently witnessing the most extensive development activity, with over 60 candidates in clinical trials, including CAB-AXL-ADC, TQB2102, and MYTX-011, and one Enhertu, approved for use in clinical setting. This reflects a strategic shift towards addressing the high-unmet medical need in lung cancer, which remains one of the leading causes of cancer mortality worldwide. The potential for antibody drug conjugates to provide more effective and less toxic treatment options makes them particularly attractive in this therapeutic area.
In contrast, however, breast cancer has experienced the highest number of antibody drug conjugates approvals to date, with four approved candidates, contributing significantly to the market's commercial success. Two key players in this domain are the aforementioned Kadcyla and Enhertu, both of which have demonstrated remarkable efficacy and have achieved significant sales milestones. The promising pipeline also includes AstraZeneca and Daiichi Sankyo's Datopotamab Deruxtecan, a TROP2-directed antibody drug conjugate that is currently under review for its use in breast cancer treatment. This continued investment in research and development underscores the critical role antibody drug conjugates play in advancing cancer care.
Regionally, the cancer antibody drug conjugates market is primarily led by the US and China, two of the largest and most dynamic pharmaceutical markets globally. In the US, robust healthcare infrastructure, high R&D expenditure, and a favorable regulatory environment foster innovation and accelerate the approval process for new therapies. Additionally, the presence of major pharmaceutical companies, such as Regeneron, Gilead, Merck and Pfizer, bolsters the competitive landscape, enabling rapid development and commercialization of antibody drug conjugates.
In China, the growing demand for advanced cancer treatments, coupled with increasing government support for biotechnology and pharmaceutical research, has catalyzed significant growth in the antibody drug conjugates sector. Local players like Mabwell, Miracogen, Chia Tai Tianqing Pharmaceutical, Hansoh BioMedical, Sichuan Baili Pharmaceuticals, Biocytogen and Affinity Biopharma are emerging as significant contributors to the market, developing novel Antibody drug conjugates tailored to the specific needs of the Chinese patient population, and out licensing promising candidates to their international counterparts through license agreements.
The global market for cancer antibody drug conjugates represents a dynamic and rapidly evolving segment of the cancer therapeutics landscape. With ongoing clinical trials, innovative research, and increasing regulatory support, antibody drug conjugates are poised to play an increasingly pivotal role in cancer treatment. As efforts continue to address existing challenges and expand the range of approved indications, the future of antibody drug conjugates appears promising, offering hope to patients worldwide in the fight against cancer. The collaborative efforts among pharmaceutical companies, regulatory bodies, and research institutions will be crucial in shaping the next wave of advancements in this exciting therapeutic field.