市场调查报告书
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1499969
全球寡核甘酸合成市场评估:依产品、类型、应用、最终用户、地区、机会、预测(2017-2031)Oligonucleotide Synthesis Market Assessment, By Product, By Type, By Application, By End-user, By Region, Opportunities and Forecast, 2017-2031F |
全球寡核甘酸合成市场规模预计将从 2023 年的 60.6 亿美元增至 2031 年的 187.6 亿美元,2024-2031 年预测期间复合年增长率为 15.17%。市场成长的推动因素包括製药和生物技术领域研发投资的增加、各公司之间的合作和伙伴关係的增加、慢性病的流行以及法医和基因检测和研究活动中使用的定制寡核甘酸的需求。
增加研发投入是寡核甘酸合成市场的全球主要趋势。2023 年 9 月,西班牙领先的製药公司之一 Insud Pharma Group 在 Chemo India Formulation Private Limited 开设了寡核甘酸中心。该研究和生产中心将专注于寡核甘酸的商业生产和研究。该设施已通过Drug Control Center of India、Spanish Health Agency和美国FDA(食品药物协会)的检查和批准。
新产品和新技术的推出为市场提供了利润丰厚的成长机会。2024 年 4 月,Asahi Kasei Bioprocess Inc.推出了最新的 Olio 製造创新产品 THESYS ACS ERGO 合成柱。此色谱柱减少了转换时间,同时保持了产品品质和用户安全。THESYS ACS ERGO 旨在透过其易于操作的设计实现安全、平稳的转换并减少批次间的低效率。THESYS ACS ERGO 的省时功能是透过在维护和更换过程中消除螺栓的使用来实现的。
併购支持市场拓展
支持市场成长的是全球各地区不断增加的併购和联盟。这些活动使公司能够成功地进行研究合作,并确保先进技术的发现、交付和开发。併购帮助公司有机扩张,提供必要的资金来推动研发活动以及新疗法和技术的开发,并支持全球寡核甘酸合成市场的成长。
2024 年 6 月,GSK plc 宣布以 5,000 万美元收购 Elsie Biotechnologies, LLC,以开发寡核甘酸疗法的潜力。寡核甘酸具有调节基因表现的独特能力,并有可能解决小分子生物製剂和分子无法实现的广泛治疗标靶。Elsie 专注于优化寡核甘酸治疗的递送、降低毒性和提高疗效。透过收购Elsie,GSK可望加强在基因调控方面的研发力道。此外,GSK 对工具学习和人工智慧的使用,与 Elsie 平台的数据相结合,预计将支援预测模型的开发,以简化未来的寡核甘酸设计。
诊断应用的增加推动市场成长
由于各种疾病和病症的流行,对寡核甘酸的需求不断增加,这增强了全球对寡核甘酸合成的需求。对于研究和诊断应用,寡核甘酸是使用多孔玻璃 (CPG) 合成的。在分子生物学中,寡核甘酸可用于使用杂交测定和聚合□炼式反应检测感兴趣的 RNA 和 DNA 序列。基于寡核甘酸的微阵列已被开发用于分析不同细胞类型和组织中的基因表现水平,且寡核甘酸探针可用于识别与遗传疾病相关的多态性和特定突变。越来越多的遗传性疾病患者增加了对用于诊断干预的寡核甘酸的需求。Epilepsy Foundation估计,每 20,000 至 40,000 人中就有 1 人患有 Dravet 症候群。
本报告研究和分析了全球寡核甘酸合成市场,提供市场规模和预测、市场动态以及主要参与者的现状和前景。
Global oligonucleotide synthesis market is projected to witness a CAGR of 15.17% during the forecast period 2024-2031F, growing from USD 6.06 billion in 2023 to USD 18.76 billion in 2031F. The market's growth is supported by the increasing investments towards research and development activities in the pharmaceutical and biotechnology sectors, rising collaborations and partnerships among various companies, growing prevalence of chronic diseases, and rising demand for custom oligonucleotides for use in forensics, genetic testing, and research activities.
Rising research and development investments are a major global trend in the oligonucleotide synthesis market. In September 2023, Insud Pharma Group, one of the leading Spanish pharmaceutical companies, inaugurated its oligonucleotide center at Chemo India Formulation Private Limited. The research and production center will focus on commercial production and research on oligonucleotides. The facility was inspected and approved by the Drug Control Center of India, Spanish Health Agency, and the US FDA (United States Food and Drug Association).
Introducing novel products and technologies provides lucrative growth opportunities to the market. In April 2024, Asahi Kasei Bioprocess Inc. unveiled their latest olio manufacturing innovation, the THESYS ACS ERGO synthesis column, which offers reduced changeover time while maintaining the quality of the product and maintaining user safety. The THESYS ACS ERGO facilitates a safe and smooth changeover between runs with the help of its operator-friendly design and is engineered to reduce inefficiencies between batches. The time-saving feature of the THESYS ACS ERGO is achieved by eliminating the utilization of threaded bolts in the maintenance and changeover process.
Mergers and Acquisitions are Supporting Market Expansion
The growth of the market is supported by the rising mergers and acquisitions and successful collaborations in various regions across the globe. These activities allow companies to follow through with successful research collaborations and ensure the discovery, delivery, and development of advanced technologies. Mergers and acquisitions aid in the company's organic expansion and provide necessary funds for driving research and development activities and development of novel therapies and technologies, thus bolstering the global oligonucleotide synthesis market growth.
In June 2024, GSK plc announced the acquisition of Elsie Biotechnologies, LLC for USD 50 million to capitalize on the potential of oligonucleotide therapeutics. The unique ability of the oligonucleotides to modulate gene expressions makes them a potential modality for addressing a wide range of therapeutic targets that might not be amenable to small biologics and molecules. Elsie is focused on optimizing delivery, reducing toxicity, and enhancing the potency of oligonucleotide therapeutics. With the acquisition of Elsie, GSK is expected to enhance its research and development efforts in gene modulation. Furthermore, the utilization of machine learning and artificial intelligence by GSK, in combination with the data from Elsie's platform, is expected to support the development of predictive models for streamlining future oligonucleotide designs.
Rising Applications in Diagnostics Bolsters the Market Growth
The rising demand for oligonucleotides due to the growing prevalence of various diseases and disorders is bolstering the global demand for oligonucleotide synthesis. For research and diagnostic applications, oligonucleotides are synthesized using controlled pore glass (CPG). In molecular biology, oligonucleotides aid in detecting the desired RNA and DNA sequences using hybridization assays and polymerase chain reactions. The oligonucleotide-based microarrays have been developed to analyze the gene expression levels in various cell types and tissues, and oligonucleotide probes can be used to identify polymorphisms and specific mutations associated with genetic disorders. The rise in the number of cases of genetic disorders is thus bolstering the demand for oligonucleotides for diagnostic interventions. According to the estimates of the epilepsy foundation, 1 in 20,000 to 1 in 40,000 individuals have Dravet Syndrome.
Therapeutics Segment to Account for Significant Global Oligonucleotide Synthesis Market Share
The growth of the segment is aided by the rising prevalence of chronic diseases and increasing utilization of oligonucleotides in drug development processes. Over the past few years' oligonucleotides have demonstrated the ability to provide patients with major therapeutic benefits, future developments are expected to boost the expansion of the segment. The segment's growth is supported by the rise in the number of collaborations to support the discovery and development of oligonucleotide therapeutics. In May 2024, Orbit Discovery Ltd. and Secarna Pharmaceuticals GmbH & Co. entered in a collaboration for developing peptide-conjugated targeted antisense oligonucleotide (ASO) therapeutics. The collaboration aims to expand Secarna's reach of antisense approaches and strengthen their ability of creating targeted antisense therapeutics, allowing them to offer novel treatment solutions for a wide range of diseases.
Additionally, the growth of the market is supported by the rising investments in companies that are focused on the development of targeted oligonucleotide therapeutics. In January 2022, Ceptur Therapeutics, Inc. announced the completion of a USD 75 million Series A financing. The biotechnology company focuses on the development of targeted oligonucleotide therapeutics that are based on U1 Adaptor Technology. Such investments are expected to support the development of novel products, propelling the expansion of the segment.
North America Accounts for Significant Market Share
The factors supporting the market's growth in North America include rising investments towards the development of advanced therapeutic solutions, rapid expansion of the healthcare and pharmaceutical sectors, and increasing prevalence of various chronic diseases. According to the estimates of the National Cancer Institute, approximately 2,001,140 cases of cancer and 611,720 deaths from the disease are expected to occur in the United States in 2024.
The growing emphasis on novel product development coupled with rising approvals from the US FDA further supports the market expansion. In June 2024, the FDA approved Geron Corporation's RYTELO (imetelstat), an oligonucleotide telomerase inhibitor for treating adults with low-to-intermediate-1 risk myelodysplastic syndromes (LR-MDS) that have transfusion-dependent anemia and require four or more units of red blood cells over eight weeks. Approval was given based on the safety and efficacy findings from the placebo-controlled, randomized, phase 3 IMerge trial.
Furthermore, rising investments in the development of oligonucleotide manufacturing facilities are supporting the expansion of the market in North America. In November 2023, Integrated DNA Technologies, Inc. opened its new therapeutic oligonucleotide manufacturing facility in Iowa, the United States. The site manufactures gene therapy reagents and cGMP cells, including donor oligos for homology-directed repair and sgRNAs (single guide RNAs).
Future Market Scenario (2024 - 2031F)
The potential applications for oligonucleotide synthesis are expected to expand over the forecast period, from gene regulation to gene editing and personalized medicine, novel applications of oligonucleotide synthesis are anticipated to emerge. Future applications and innovations are expected to increasingly focus on personalized medicines and the designing of oligonucleotides that are capable of targeting specific genomic regions or mutations, strengthening the possibility of developing therapies tailored to specific patient requirements, thus facilitating the growth of the market in the forecast period.
Furthermore, the rise in the number of research activities that use oligonucleotides as interventions or treatments is expected to support the expansion of the market in the coming years. The University College London (UCL) is conducting an interventional study, which is expected to conclude in August 2025, to assess if the drug NIO752 reduces the production of tau protein by the brain. In normal conditions tau is responsible for stabilizing neuronal microtubules, however in Alzheimer's the protein builds up in the brain and causes damage.
Key Players Landscape and Outlook
The rising investments by companies across the globe towards developing oligonucleotide manufacturing facilities is expected to boost the global oligonucleotide synthesis market size. Companies are increasingly focusing on forming strategic partnerships and alliances to support such development activities. In April 2024, Axolabs Gmbh and Asahi Kasei Bioprocess Inc. (AKB), part of the Asahi Kasei Group, announced a partnership to build a cGMP manufacturing facility in Berlin to accelerate the commercialization and development of oligonucleotide-based therapies.
Such investments are increasing as oligonucleotide therapies offer targeted approaches for protein production and gene expression modulation and can potentially treat a broad range of diseases. At present, the FDA has approved eighteen oligonucleotide drugs.
Additionally, the market's growth is supported by the rising investments by the key market players in oligonucleotide manufacturing suites. In March 2024, Merck announced the opening of its first cGMP Oligonucleotide Manufacturing suite in Missouri, the United States. The development is expected to enhance the company's oligo offerings to include cGMP quality oligos tailored for clinical and diagnostic markets.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work