市场调查报告书
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糖基辅料市场——增长、趋势、COVID-19 的影响和预测 (2023-2028)Sugar-Based Excipients Market - Growth, Trends, and Forecasts (2023 - 2028) |
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在预测期内,糖基辅料市场预计将以 4.6% 的复合年增长率增长。
在 COVID-19 大流行期间,药用辅料公司面临重大挑战,例如药品短缺,全球停工中断了来自製造基地的全球原材料供应链。 这些限制阻碍了药物研究和製造过程,并对依赖外包的公司产生了重大影响。 此外,在 COVID-19 疫苗中越来越多地使用糖基辅料对市场产生了积极影响。 例如,根据康涅狄格州卫生部 2021 年 4 月的审查,辉瑞-BioNTech 疫苗含有一种碱性食糖,通常称为蔗糖,用作疫苗稳定剂。 这种成分有助于在冷冻时保持分子的形状。 因此,在 COVID-19 大流行期间,糖基辅料市场预计会产生初步的负面影响,但随后 COVID-19 药物和疫苗配方中使用糖基辅料,预计会受到影响.
市场增长的主要驱动力是共加工辅料的使用增加、仿製药市场的快速增长以及口腔崩解片的不断发展。 例如,根据 2022 年 12 月发表在 APhP 上的一份报告,现有辅料的新组合可用于改善辅料的功能,包括口腔崩解片中令人愉悦的味道、口感和甜味,这是一个有趣的选择。 因此,共加工辅料的上述优势有望增加对碳水化合物辅料(药物成分之一)的需求,并推动市场增长。
此外,对口腔崩解片的日益偏爱及其发展正在推动市场。 口腔崩解片与传统片剂的不同之处在于,它们被设计为在舌头上溶解而不是整个吞嚥。 随着老年人口和儿科患者数量的增加,对口腔崩解片的需求也在增加。 例如,根据 MDPI 于 2022 年 8 月发表的研究,糖和糖醇由于其高水溶性和改善口味的特性,长期以来一直受到口腔崩解製剂领域的关注。 因此,开髮用于生产口腔分散製剂的一些赋形剂组合包含单醣和/或相应的醇。 糖和糖醇与其他赋形剂一起使用,以确保片剂的均匀性和结构完整性。 因此,由于上述糖基辅料在口腔分散片中的优势,预计糖基辅料市场将会增长。
然而,对糖基赋形剂产品的严格监管要求预计将抑制市场增长。
由于其无毒和高效,糖醇越来越多地用于口服处方和儿科製剂,预计将占据全球市场的最大份额。 糖醇,也称为多元醇,是用作甜味剂和填充剂的成分。 糖醇,也称为多元醇,是用作甜味剂和填充剂的成分,可掩盖活性剂的苦味并改善其适口性。
不断上升的生育率和不断增加的儿科患者数量是推动这一领域市场增长的主要因素。 醣类无毒,药物反应可忽略不计,因此主要用于口服製剂。 根据 Childstats.gov 2022,2021 年美国 0-17 岁儿童人数估计为 7360 万,预计到 2050 年将增至 7820 万。 因此,预计不断增长的儿科人口将推动对碳水化合物配方的需求,从而促进该领域的增长。
此外,糖醇在製药领域的一些附加优势帮助了该领域的增长。 例如,根据 AAPS 杂誌 2022 年 1 月发表的一份报告,已知糖醇山梨糖醇和甘露糖醇在口服时具有很强的渗透作用。 因此,糖醇被广泛使用,预计将在预测期内推动市场。
北美的糖基辅料市场经历了显着增长,预计在预测期内将保持这种增长。 製药行业的快速扩张、对功能性赋形剂的需求不断增长、该地区有影响力的参与者的存在以及技术进步等因素预计将在预测期内推动市场扩张。
根据 CDC 于 2021 年 11 月发布的一份报告,糖基赋形剂被用作稳定剂,以在运输和储存过程中保持疫苗的效力。 同样根据上述来源,以蔗糖为赋形剂的疫苗包括流感(Afluria)四价、流感(FluMist)四价、MenB(Bexsero)、MMRV(ProQuad)、轮状病毒(RotaTeq)等。 因此,这些糖基赋形剂在该地区被广泛用作稳定剂,预计将在预测期内推动市场。
此外,市场进入者采取的战略行动(例如产品发布、併购)也有助于细分市场的增长。 例如,2021 年 12 月,罗盖特集团加强了在美洲的製药业务扩张,以加强其全球领导地位,并突出其对以客户为中心的创新的承诺。 因此,预计主要市场参与者的这些战略行动将有助于促进产品在该地区的渗透,并在研究期间提振市场。
糖基辅料市场由几家大型企业组成,竞争相对激烈。 目前主导市场的公司包括 DFE Pharma、Archer Daniels Midland Company、Ashland Inc.、Roquette Group、The Lubrizol Corporation、Associated British Foods PLC、Cargill, Inc、Colorcon Inc、FMC Corporation 和 Megle AG。
The sugar-based excipients market is projected to grow with a CAGR of 4.6% over the forecast period.
During the COVID-19 pandemic, pharmaceutical excipients companies faced significant problems, such as a shortage of medicinal items, and shutdown measures worldwide damaged the global supply chain of raw materials from manufacturing hubs. These restrictions hampered the medication research and manufacturing processes and had a significant impact on the corporations that rely on outsourcing. Moreover, the growing use of sugar-based excipients in the COVID-19 vaccines positively impacted the market. For instance, according to the review by the Connecticut Department of Health in April 2021, the Pfizer-BioNTech vaccine contains basic table sugar, generally known as sucrose, which is used as a stabilizer in vaccines. This component aids in the preservation of the molecules' form upon freezing. Thus, during the COVID-19 pandemic, the sugar-based excipients market is expected to have an adverse impact initially, later due to the use of sugar-based excipients in COVID-19 drug and vaccine formulations which is likely to gain market growth over the study period.
The major factor attributing to the growth of the market is the increasing use of co-processed excipients, the rapid growth of the generic market, and the increasing development of orally disintegrating tablets. For instance, as per the report published by the journal of APhP in December 2022, new combinations of existing excipients are an interesting option for improving excipient functionality which includes pleasant taste, mouth feel, and sweetness in orally disintegrating tablets. Thus, due to the above benefits of the co-processed excipient, the demand for sugar-based excipients is expected to grow, as it is one of the ingredients in the pharmaceutical product, thereby boosting the market growth.
Furthermore, the growing preference for orally disintegrating tablets and their development is boosting the market. Orally disintegrating tablets differ from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole. As the number of geriatric population and pediatric patients increases, the demand for orally disintegrating tablets is increasing. For instance, according to the study published by MDPI in August 2022, saccharides and sugar alcohols have long been of interest in the area of orodispersible formulations due to their high-water solubility and taste-improving properties. As a result, several excipient combinations developed to manufacture orally dispersible dosage forms contain monosaccharides and/or their respective alcohols. Sugars or sugar alcohols, together with other excipients, are used to ensure the tablets' uniformity and structural integrity. The market for sugar-based excipients is therefore projected to rise as a result of the aforementioned advantages of sugar-based excipients in orally dispersible tablets.
However, the stringent regulatory requirements for sugar-based excipient products are expected to restrain market growth.
The sugar alcohol segment is expected to account for the largest share in the global market owing to its increased utilization in oral prescription medicines and pediatric formulations due to its non-toxicity and high efficiency. Sugar alcohols, also known as polyols, are ingredients used as sweeteners and bulking agents. They can be used to conceal the bitter taste of active agents, thereby making them more palatable.
The major factors increasing the market growth of the segment are the increasing birth rate and the growing pediatric patient pool. The actual sugars are used mainly in oral formulations due to their non-toxicity and negligible reaction with drugs. According to Childstats.gov 2022, the number of children aged 0-17 years in the United States is estimated at 73.6 million in 2021 and is likely to increase to 78.2 million by 2050. Thus, increasing the pediatric population is expected to drive the demand for sugar-based formulations, thereby boosting segment growth.
Additionally, some of the additional advantages of sugar alcohols in the pharmaceutical field help in the growth of the segment. For instance, as per the report published by the AAPS Journal in January 2022, when taken orally, the sugar alcohols sorbitol and mannitol are known to provide a strong osmotic effect. Hence, widespread applications of sugar alcohols it is expected to drive the market over the forecast period.
North America is expected to have significant growth in the sugar-based excipients market and is likely to maintain this over the forecast period. Factors such as the rapidly expanding pharmaceutical sector, the rising need for functional excipients, the presence of significant players in the region, and technological advances will drive market expansion throughout the projection period.
According to the report published by CDC in November 2021, sugar-based excipients are used as stabilizers to keep the vaccine potent during transportation and storage. Also, as per the same above-mentioned source, some of the vaccines in which sucrose is used as an excipient include Influenza (Afluria)Quadrivalent, Influenza (FluMist) Quadrivalent, MenB (Bexsero), MMRV (ProQuad), and Rotavirus (RotaTeq). Hence, the wide usage of these sugar-based excipients in the region as stabilizers is expected to drive the market over the forecast period.
Furthermore, strategic actions done by market participants, such as product launches, mergers, and acquisitions, contribute to the market segment's growth. For instance, in December 2021, Roquette Group intensified its pharmaceutical business expansion in the Americas to consolidate its worldwide leadership and underline its commitment to customer-focused innovation. Hence, these strategic actions of the major market players help in the widespread of the products in the region and are expected to boost the market over the study period.
The Sugar-Based Excipients market is moderately competitive and consists of several major players. Some of the companies which are currently dominating the market are DFE Pharma, Archer Daniels Midland Company, Ashland Inc., Roquette Group, The Lubrizol Corporation, Associated British Foods PLC, Cargill, Inc., Colorcon Inc., FMC Corporation, and Meggle AG.